董德利

董德利,博士药理学二级教授,博士生导师,中国药理学会表观遗传药理学专业委员会副主任委员,中国药理学会心血管专业委员会常务委员;《药学学报》编委Acta Pharmaceutica Sinica B 编委;国家自然基金一审、二审专家1993年本科毕业于中国药科大学药理学专业,1999年硕士毕业于哈尔滨医科大学药理学专业,2004年博士毕业于哈尔滨医科大学药理学专业19998月至20008月于加拿大卡尔加里大学医学院访问学者,20061月至20077月于美国纽约医学院访问学者;主持承担国家自然科学基金重大研究计划项目1国家自然科学基金面上项目5项及其他省部级项目11项;曾获全国优秀博士学位论文和美国心脏学会Hypertension杂志Top论文奖Hypertension, Br J Pharmacol, Basic Res Cardiol, Cardiovasc Res等国际专业期刊发表第一/通讯作者SCI论文53篇,获授权发明专利7副主编数字教材《药理学》(人民卫生出版社出版2015参编《药理学》普通高等教育十五国家级规划教材《分子药理学》高等教育出版社研究生用书2007《离子通道药理学》(人民卫生出版社 2005)等Hypertension, Br J Pharmacol, Journal of Medicinal Chemistry等杂志审稿人。

研究方向:

(一)心肌肥厚/心衰发生机制及药物作用研究

(二)线粒体解偶联剂的药理学作用特征及新药发现研究

联系方式:

 Email: delidong2004@aliyun.com; 电话:13274602909

代表性第一/通讯作者SCI论文:

1. Zhao J, Gao JL, Zhu JX, Zhu HB, Peng X, Jiang M, Fu Y, Xu J, Mao XH, Hu N, Ma MH, Dong DL*.The different response of cardiomyocytes and cardiac fibroblasts to mitochondria inhibition and the underlying role of STAT3.Basic Res Cardiol. 2019;114(2):12.

2. Gao JL, Zhao J, Zhu HB, Peng X, Zhu JX, Ma MH, Fu Y, Hu N, Tai Y, Xuan XC, Dong DL*.Characterizations of mitochondrial uncoupling induced by chemical mitochondrial uncouplers in cardiomyocytes.Free Radic Biol Med. 2018;124:288-298.

3. Liu MY, Jin J, Li SL, Yan J, Zhen CL, Gao JL, Zhang YH, Zhang YQ, Shen X, Zhang LS, Wei YY, Zhao Y, Wang CG, Bai YL, Dong DL*. Mitochondrial Fission of Smooth Muscle Cells Is Involved in Artery Constriction.Hypertension.2016; 68:1245-1254.

4. Sun B, Huo R, Sheng Y, Li Y, Xie X, Chen C, Liu HB, Li N, Li CB, Guo WT, Zhu JX, Yang BF, Dong DL*. Bone Morphogenetic Protein-4 Mediates Cardiac Hypertrophy, Apoptosis, and Fibrosis in Experimentally Pathological Cardiac Hypertrophy. Hypertension. 2013; 61: 352-360. (获Hypertension杂志Top论文奖)

5. Dong DL*, Chen C, Huo R, Wang N, Li Z, Tu YJ, Hu JT, Chu X, Huang W, Yang BF. Reciprocal Repression between MicroRNA-133 and Calcineurin Regulates Cardiac Hypertrophy: A Novel Mechanism for Progressive Cardiac Hypertrophy. Hypertension. 2010;55:946-952.

6. Dong DL, Zhang Y, Lin DH, Chen J, Patschan S, Goligorsky MS, Nasjletti A, Yang BF, Wang WH. Carbon Monoxide Stimulates the Ca2+–activated Big Conductance K (BK) Channels in Cultured Human Endothelial Cells.Hypertension. 2007; 50:643-651.

7. Xiao XL, Hu N, Zhang XZ, Jiang M, Chen C, Ma R, Ma ZG, Gao JL, Xuan XC, Sun ZJ, Dong DL*.Niclosamide inhibits vascular smooth muscle cell proliferation, migration, and attenuates neointimal hyperplasia in injured rat carotid arteries.Br J Pharmacol. 2018;175(10):1707-1718.

8. Zhang YQ, Shen X, Xiao XL, Liu MY, Li SL, Yan J, Jin J, Gao JL, Zhen CL, Hu N, Zhang XZ, Tai Y, Zhang LS, Bai YL, Dong DL*. Mitochondrial uncoupler CCCP induces vasorelaxation without involving KATP channel activation in smooth muscle cells of arteries. Br J Pharmacol. 2016;173(21):3145-3158.

9. Xie X, Zhao Y, Ma CY, Xu XM, Zhang YQ, Wang CG, Jin J, Shen X, Gao JL, Li N, Sun ZJ,DongDL*. Dimethyl fumarate induces necroptosis in colon cancer cells through glutathione depletion/ROS increase/MAPKs activation pathway. Br J Pharmacol. 2015;172(15):3929-3943.

10. Wang YC, Xiao XL, Li N, Yang D, Xing Y, Huo R, Liu MY, Zhang YQ,Dong DL*.Estrogen inhibits BMP4-induced BMP4 expression in cardiomyocytes: a potential mechanism of estrogen-mediated protection against cardiac hypertrophy.Br J Pharmacol. 2015, 172(23):5586–5595.

11. Sheng Y,Sun B, Guo WT, Liu X, Wang YC, Xie X, Xiao XL, Li N,Dong DL*. DMH1 (4-[6-(4-Isopropoxyphenyl)pyrazolo [1,5-a]pyrimidin-3-yl] quinoline) is a novel autophagy inhibitor. Br J Pharmacol. 2014;171(21):4970-80.

12. Li SL, Yan J, Zhang YQ, Zhen CL, Liu MY, Jin J, Gao JL, Xiao XL, Shen X, Tai Y, Hu N, Zhang XZ, Sun ZJ,Dong DL*. Niclosamide ethanolamine inhibits artery constriction.Pharmacol Res. 2017; 115: 78-86.

13. Deli Dong, Yanjun Duan, Jiqingguo, Dan E. Roach, Shauni L Swirp, Li Wang, J.P.Lees-Miller, R.S.Sheldon, Jeffery D. Molkentin, Henry J Duff. Overexpression of Calcineurin in Mouse Ventricle Causes Sudden Cardiac Death Associated with Decreased Density of K+ Channels. Cardiovasc Res. 2003;57:320-332.

14. Bai YL, Liu HB, Sun B, Zhang Y, Li Q, Hu CW, Zhu JX, Gong DM, Teng X, Zhang Q, Yang BF, Dong DL*. HIV Tat protein inhibits hERG K+ channels: a potential mechanism of HIV infection induced LQTs. J Mol Cell Cardiol. 2011;51(5):876-880.

15. Li Q, Zhang Y, Sheng Y, Huo R, Sun B, Teng X, Li N, Zhu JX, Yang BF, Dong DL*. Large T antigen up-regulates Kv4.3 K+ channels through Sp1 and Kv4.3 K+ channels contribute to cell apoptosis and necrosis through activation of calcium/calmodulin-dependent protein kinase II.Biochem J. 2012,441(3): 859-867.

16. Hu CW, Li Q, Zhang Y, Li YH, Jiang HC, Liu MY, Li SL, Han W, Dong DL*. Bone morphogenetic protein-4 induces upregulation of Cav3.1 Ca2+ channels in HL-1 atrial myocytes. Pflugers Arch. 2014;466(11):2049-2057.

17. Lu J, Sun B, Huo R, Wang YC, Yang D, Xing Y, Xiao XL, Xie X, Dong DL*. Bone morphogenetic protein-2 antagonizes bone morphogenetic protein-4 induced cardiomyocyte hypertrophy and apoptosis. J Cell Physiol. 2014; 229: 1503-1510.

18. Tai Y, Li L, Peng X, Zhu J, Mao X, Qin N, Ma M, Huo R, Bai Y, Dong D*.Mitochondrial uncoupler BAM15 inhibits artery constriction and potently activates AMPK in vascular smooth muscle cells.Acta Pharm Sin B. 2018;8(6):909-918.

19. Jin J, Shen X, Tai Y, Li S, Liu M, Zhen C, Xuan X, Zhang X, Hu N, Zhang X, Dong D*.Arterial relaxation is coupled to inhibition of mitochondrial fission in arterial smooth muscle cells: comparison of vasorelaxant effects of verapamil and phentolamine.Acta Pharm Sin B. 2017;7(3):319-325.

20. Zhang X, Zhang X, Zhang Y, Liu M, Jin J, Yan J, Shen X, Hu N, Dong D*.Mitochondrial uncoupler triclosan induces vasorelaxation of rat arteries.Acta Pharm Sin B. 2017;7(6):623-629.

21. Huo R, Sheng Y, Guo WT, Dong DL*.The potential role of Kv4.3 K+ channel in heart hypertrophy. Channels (Austin). 2014;8(3).

22. Guo WT, Dong DL*. Bone morphogenetic protein-4: a novel therapeutic target for pathological cardiac hypertrophy/heart failure.Heart Fail Rev. 2014;19(6):781-788.

23. Dong DL, Bai YL, Cai BZ. Calcium-Activated Potassium Channels: Potential Target for Cardiovascular Diseases. In Rossen Donev, editor: Ion channels as therapeutic targets, part B, Vol 104, Advances in Protein Chemistry and Structural Biology.UK: Academic Press, 2016, 233-261.(专著-Book)