王欣之

王欣之,博士,副研究员,硕士生导师。2010年本科毕业于中国药科大学药学院。2015年博士毕业于中国药科大学,主要从事免疫毒理学的研究。博士毕业后在中国药科大学药物科学研究院新药筛选中心任职。2019-2020年赴美国得克萨斯州大学埃尔帕索分校任访问学者。以第一作者或通讯作者发表SCI论文12篇。

联系方式:wangxz@cpu.edu.cnwangxzcpu@163.com

研究内容:

1.免疫细胞在中药诱导肝损伤中的作用机制

2.胆汁淤积性肝损伤的免疫治疗靶点发现

主持项目:

1.基于iNKT17细胞功能调控的雌激素诱导肝内胆汁淤积新靶点发现,国家自然科学基金面上项目(82073948

2. NKT细胞经由CD1dTLR调控活化在雷公藤甲素肝毒性中的作用机制研究,国家自然科学基金青年项目(81703626

3. NKT细胞经由HMGB1-TLR2-MyD88-NFκB信号通路参与雷公藤甲素诱导肝损伤的机制研究,中央高校基本科研业务费培育项目(2632017PY11

代表性论文:

1Zou Mengzhi#, Nong Cheng#, Yu Zixun, Cai Heng, Jiang Zhenzhou, Xue Rufeng, Huang Xin, Sun Lixin, Zhang Luyong*, Wang Xinzhi*. The role of invariant natural killer T cells and associated immunoregulatory factors in triptolide-induced cholestatic liver injury.Food and Chemical Toxicology, 2020, 146: 111777.

2Nong Cheng, Zou Mengzhi, Xue Rufeng, Bai Li, Liu Li, Jiang Zhenzhou, Sun Lixin, Huang Xin, Zhang Luyong*, Wang Xinzhi*. The role of invariant natural killer T cells in experimental xenobiotic-induced cholestatic hepatotoxicity. Biomedicine & Pharmacotherapy, 2020, 122: 109579.

3王欣之, 农程, 江振洲, 张陆勇. 雷公藤甲素对脾脏Th17/Treg细胞的影响. 中国中药杂志, 2019, 44(15): 3330-3334.

4Wang Xinzhi, Xue Rufeng, Zhang Shenye, Zheng Yating, Zhang Luyong*, Jiang Zhenzhou*. Activation of natural killer T cells contributes to triptolide-induced liver injury in mice. Acta Pharmacologica Sinica, 2018, 39(12): 1847-1854.

5Wang Xinzhi, Zhang Shenye, Xu Yao, Zhang Luyong*, Jiang Zhenzhou*. The role of neutrophils in triptolide-induced liver injury. Chinese Journal of Natural Medicines, 2018, 16(9): 653-664. 

6Wang Xinzhi, Sun Lixin, Zhang Luyong*, Jiang Zhenzhou*, Effect of adoptive transfer or depletion of regulatory T cells on triptolide-induced liver injury, Frontiers in Pharmacology, 2016, 7: 99.

7Wang Xinzhi, Zhang Luyong*, Jiang Zhenzhou*, T-Helper cell-mediated factors in drug-induced liver injury, Journal of Applied Toxicology, 2015, 35: 695-700. (review)  

8Wang Xinzhi#, Jiang Zhenzhou #, Cao Weiping, Yuan Ziqiao, Sun Lixin, Zhang Luyong*, Th17/Treg imbalance in triptolide-induced liver injury, Fitoterapia, 2014, 93: 245–251. 

9Wang Xinzhi, Jiang Zhenzhou*, Xing Mengtao, Fu Jing, Su Yuwen, Sun Lixin, Zhang Luyong*, Interleukin-17 mediates triptolide-induced liver injury in mice, Food and Chemical Toxicology, 2014, 71: 33-41