惠慧

惠慧,1986年9月出生,药理学博士,副教授,硕士生导师,主要研究方向:1、白血病发病机制和药物作用靶点探究;2、抗白血病药物的体内外筛选及分化诱导机制研究;迄今已在血液学顶级杂志BLOOD、international journal of cancer等期刊发表SCI论文11篇。目前主持国家自然科学基金,江苏省自然科学基金等课题项目。


Hui Hui was born in September 1986, who is Ph.D. of pharmacology, associate professor and master tutor. Main research direction includes: 1, To explore the pathogenesis of leukemia and drug targets; 2, The anti-leukemia drugs in vitro and in vivo screening and mechanism of differentiation induction. So far, 12 SCI papers have been published in the top journals of Hematology such as BLOOD, International Journal of cancer and other periodicals. At present, the National Natural Science Foundation of China and the Natural Science Foundation of Jiangsu province are being presided. 

Email: moyehh@163.com


Representative articles:

1.Oroxylin A,a natural compound, mitigates the negative effects of TNFα-treated acute myelogenous leukemia cells, Li Hui ; Lu Na ; Yu Xiaoxuan; Liu Xiao; Hu Po; Zhu Yu; Shen Le; Xu Jingyan; Li Zhiyu; Guo Qinglong* ;Hui Hui*. Carcinogenesis. 2018 Jan 13. (IF2017=5.105)

2.PLSCR1/IP3R1/Ca2+ axis contributes to differentiation of primary AML cells induced by wogonoside. Li H, Xu J, Zhou Y, Liu X, Shen LE, Zhu YU, Li Z, Wang X, Guo Q*, Hui H*. Cell Death Dis. 2017 May 11;8(5):e2768. (IF2017=5.965)

3.Oroxylin A inhibits the generation of Tregs in non-small cell lung cancer.Shen L, Zhang LL, Li H, Liu X, Yu XX, Hu P, Hui H*, Guo QL*, Zhang S*. Oncotarget. 2017 Jul 25;8(30):49395-49408. (IF2017=5.168)

4.Oroxylin A, a natural anticancer flavonoid compound, induces differentiation of t(8;21)-positive Kasumi-1 and primary acute myeloid leukemia cells. Hui H, Zhang X, Li H, Liu X, Shen L, Zhu Y, Xu J*, Guo Q*, Lu N*. J Cancer Res Clin Oncol. 2016 Jul; 142(7):1449-59. (IF2015=3.141)

5.Hui Li,Hui Hui(co-contributing author),Jingyan Xu,Hao Yang,Xiaoxiao Zhang,Xiao Liu,Yuxin Zhou,Zhiyu Li,Qinglong Guo*,Na Lu*. Wogonoside induces growth inhibition and cell cycle arrest via promoting the expression and binding activity of GATA-1 in chronic myelogenous leukemia cells. Arch Toxicol (2016) 90:1507–1522. (IF2015= 6.637)

6.Chen Y, Hui H(co-contributing author), Li Z, Wang HM, You QD, Lu N*. Gambogic acid induces growth inhibition and differentiation via upregulation of p21waf1/cip1 expression in acute myeloid leukemia cells. J Asian Nat Prod Res. 2014 Oct;16(10):1000-8. (IF2013=1.642)

7.Hui H, Yang H, Dai Q, Wang Q, Yao J, Zhao K, Guo Q*, Lu N*. Oroxylin A inhibits ATRA-induced IL-6 expression involved in retinoic acid syndrome by down-regulating CHOP. Gene. 2014 Nov 10;551(2):230-5. (IF2013=2.082)

8.Yang H, Hui H(co-contributing author), Wang Q, Li H, Zhao K, Zhou Y, Zhu Y, Wang X, You Q, Guo Q, Lu N. Wogonin induces cell cycle arrest and erythroid differentiation in imatinib-resistant K562 cells and primary CML cells. Oncotarget. 2014 Sep 30;5(18):8188-201. (IF2013=6.627)

9.Hui Hui, Yan Chen, Hao Yang, Kai Zhao, Qian Wang, Li Zhao, Xiaotang Wang, Zhiyu Li, Na Lu, and Qinglong Guo*, Oroxylin A has therapeutic potential in acute myelogenous leukemia by dual effects targeting PPARγ and RXRα. International journal of cancer, 134(5): 1195-206, 2014. (IF2013=6.198)

10.Yan Chen, Hui Hui(co-contributing author), Hao Yang, Kai Zhao, Yan Su Qin, Cong Gu, Tang xiao Wang, Lu Na, and Long qing Guo*, Wogonoside induces cell cycle arrest and differentiation by increasing expression and influencing subcellular localization of PLSCR1 in AML cells, Blood, 121(18), 3682-91, 2013 (IF2013=9.06)

11.Na Lu, Hui Hui(co-contributing author), Hao Yang, Kai Zhao, Yan Chen, Qi-Dong You, Qing-Long Guo*, Gambogic Acid inhibits angiogenesis through inhibiting PHD2-VHL-HIF-1α pathway, European Journal of Pharmaceutical Sciences, 49(2), 220-6, 2013 (IF2013=2.987)