朱启华

   朱启华,中国药科大学,药学院,副教授。主要从事新药分子的设计与合成、药物合成新技术与新工艺等方向的研究工作。近年来,专注于镇痛、抗炎和抗肿瘤药物的研究。针对肿瘤耐药的多靶点抑制剂的设计与合成、药物合成新技术和新工艺等方面开展了多年的研究。目前,主持国家自然科学基金2项,江苏省自然科学基金1项;参与国家自然科学基金(1项),国家重大新药创制科技重大专项(2项),省部级科技计划(2项)和横向开发项目(1项)的研究工作。其中在Organic Letters, European Journal of Medicinal Chemistry European Journal of Organic Chemistry, Bioorganic Medicinal Chemistry, Bioorganic Medicinal Chemistry Letter等期刊发表SCI论文16篇。获得授权专利8个。

代表论文(近两年):

1.Junwei Wang, Qiao Song, Anhua Xu, Yu Bao, Yungen Xu*, Qihua Zhu*, Design, synthesis and biological evaluation of aminobenzyloxyarylamide derivatives as selective k opioid receptor antagonists, Eur J Med Chem., 2017, 130 (1): 15-25;

2.Xin He, Yizhu Xu, Lingxuan, Kong, Huanhuan Wu, Dezhong Ji, Zhibin Wang, Yungen Xu*, Qihua Zhu*, Copper(I) and N- fluorobenzenesulfonimide-mediated direct regioselective halogenation of 8-amidoquinolines on the C5 position, Org Chem Front., 2017, 4, 1046-1050;

3.Lingzhi Zhang, Tantan Bu, Xiaobo Bao, Tingting Liang, Yiren Ge, Yungen Xu, Qihua Zhu, Design, synthesis and biological evaluation of novel 3H-imidazole[4,5-b] pyridine derivatives as selective mTOR inhibitors. Bioorg Med Chem Lett., 2017, 27 (15): 3395-3398;

4.Dongxing Chen, Jinyu Shi, Jing Liu, Xueying ZhangXiaoying DengYanyan YangShuang Cui, Qihua Zhu*, Guoqing GongYungen Xu*, Design, synthesis and antithrombotic evaluation of novel non-peptide thrombin inhibitorsBioorg Med Chem., 2017, 25(2): 458~470;

5.Dezhong Ji, Xin He, Yizhu Xu, Ziyue Xu, Yuchen Bian, Weixing Liu, Qihua Zhu*, Yungen Xu*, Metal-Free Remote C–H Bond Amidation of 8-Amidoquinolines on the C5 Position under Mild Conditions, Org Lett., 2016, 18 (18): 4478-4481;

6.Hui Li, Yan Hu, Xueyan Wang, Guangwei He, Yungen Xu*, Qihua Zhu*, Novel tricyclic poly (ADP-ribose) polymerase-1/2 inhibitors with potent anticancer chemopotentiating activity: Design, synthesis and biological evaluation, Bioorg. Med. Chem, 2016, 24, 4731-4740;

  

联系方式15951930589Emailzhuqihua@vip.126.comzhuqihua@cpu.edu.cn