林爱俊

林爱俊 (Aijun Lin),中国药科大学药学院药物化学系教授,博士生导师。2005-2011, 南京大学化学化工学院有机化学专业硕/博连读,获博士学位。2011-2012年,南京大学化学化工学院/生命科学学院博士后。2012-2014年,美国德州农工大学(Texas A&M University)化学系博士后。20145月入职中国药科大学药学院药物化学系,任副教授。20173月起,任校特聘研究员。20187月,破格晋升为教授。博士论文《有机催化不对称碳杂键形成反应研究》获2012Eli Lilly Asia Outstanding Thesis Award。至今以第一或通讯作者在Nat. CommunAngew. Chem. Int. EdACS CatalGreen ChemChem CommOrg. LettChem. Eur-JAdv. Synth. CatalJ. Org. Chem等国际知名期刊上发表SCI论文60余篇。参与编写专著一章节:林爱俊、朱成建,第9串联的不对称催化反应,《不对称催化新概念与新方法》,丁奎岭、范青华主编,化学工业出版社,2009年出版。热忱欢迎有志于有机合成化学和药物化学的本科生、硕士和博士研究生加入课题组从事基础科学研究。

  

联系方式:

Lab: 药学院新科研大楼528实验室

Emailajlin@cpu.edu.cn

  

课题组研究内容:

1.有机合成方法学研究(不对称催化与合成、惰性C-H键官能化、多组分串联反应),重点研究合成方法在复杂药物分子和活性先导化合物中的应用

2.目标导向的功能性杂环化合物的设计与合成,生物活性测试与评价,探索并发现潜在药物分子

3.生物活性天然产物全合成、结构修饰以及基于天然产物活性骨架的创新药物研发

  

近三年代表性工作:

1. Zhenbo Yuan, Yuye Zeng, Ziwen Feng, Zhe Guan, Aijun Lin* and Hequan Yao*. Constructing Chiral Bicyclo[3.2.1]octanes via Palladium-Catalyzed Asymmetric Tandem Heck/Carbonylation Desymmetrization of Cyclopentenes. Nat. Commun. 2020, accepted. (IF = 11.88)

2. Zhenbo Yuan, Ziwen Feng, Yuye Zeng, Xiaobin Zhao, Aijun Lin* and Hequan Yao*. PalladiumCatalyzed Asymmetric Intramolecular Reductive Heck Desymmetrization of Cyclopentenes: Access to Chiral Bicyclo[3.2.1]octanes. Angew. Chem. Int. Ed.2019, 58, 2884−2888. (IF = 12.26, Hot Paper)

3. Chunhua Han, Zhiyuan Fu, Songjin Guo, Xinxin Fang, Aijun Lin* and Hequan Yao*. Palladium-Catalyzed Remote 1,n-Arylamination of Unactivated Terminal Alkenes. ACS Catal.2019, 9, 4196−4202. (IF = 12.22)

4. Panpan Li, Qiuyu Li, He Weng, Jiaming Diao, Hequan Yao* and Aijun Lin*. Intramolecular Remote C-H Activation via Sequential 1,4-Palladium Migration to Access Fused Polycycles. Org. Lett. 201921, 6765−6769 (IF: 6.56)

5. Rui Pan, Cong Shi, Dongquan Zhang, Yang Tian, Songjin Guo, Hequan Yao* and Aijun Lin*. Nickel-Catalyzed Reductive 1,2-Dialkynylation of Alkenes Bearing an 8-Aminoquinoline Directing Group. Org. Lett.2019, 21, 8915−8920. (IF: 6.56)

6. Songjin Guo, Rui Pan, Zhe Guan, Panpan Li, Libo Cai, Siwei Chen, Aijun Lin* and Hequan Yao*. Synthesis of Indole-Fused Polycyclics via Rhodium-Catalyzed Undirected C-H Activation/Alkene Insertion. Org. Lett.2019, 21, 6320−6324. (IF: 6.56)

7. Songjin Guo, Panpan Li, Zhe Guan, Libo Cai, Siwei Chen, Aijun Lin,* Hequan Yao*. Pd-Catalyzed Alkyne Insertion/C−H Activation/[4+2] Carboannulation of Alkenes to the Synthesis of Polycyclics. Org. Lett.2019, 21, 921−925. (IF = 6.56, Hightlighted by Synfact)

8. Kai Yuan, Lina Liu, Jiayi Chen, Songjin Guo, Hequan Yao* and Aijun Lin*. Palladium-Catalyzed Cascade Heck Cyclization to Access Bisindoles. Org. Lett.2018, 20, 3477−3481. (IF: 6.56)

9. Xiaoying Xu,† Kaifan Zhang,† Panpan Li, Hequan Yao* and Aijun Lin*. [3 + 3] Cycloaddition of Azides with in Situ Formed Azaoxyallyl Cations to Synthesize 1,2,3,4-Tetrazines. Org. Lett.2018, 20, 1781−1784. (†equal contribution) (IF: 6.56)

10. Rui Pan, Lingyin Hu, Chunhua Han, Aijun Lin* and Hequan Yao*. Cascade Radical 1,6-Addition/Cyclization of para-Quinone Methides: Leading to Spiro[4.5]deca-6,9-dien-8-ones. Org. Lett.2018, 20, 1974−1977. (IF: 6.56)

11. Xinxin Fang, Yuye Zeng, Qiuyu Li, Zijun Wu, Hequan Yao* and Aijun Lin*. Redox-Neutral Atom-Economic Pd(0)-Catalyzed Dearomatization of beta-Naphthols with Alkynes toward Naphthalenones. Org. Lett.2018, 20, 2530−2533. (IF: 6.56)

12. Xinxin Fang, Qiuyu Li, Rui Shi, Hequan Yao* and Aijun Lin*. Controllable Pd-Catalyzed Allylation of Indoles with Skipped Enynes: Divergent Synthesis of Indolenines and N-Allylindoles. Org. Lett.2018, 20, 6084−6088. (IF: 6.56)

13. Shang Gao, Hao Liu, Zijun Wu, Hequan Yao*, Aijun Lin*. Palladium-Catalyzed Allylic Alkylation with Internal Alkynes to Construct C-C and C-N Bonds in Water. Green Chem.2017, 19, 1861−1865. (IF = 9.41)

14. Jiuan Zheng, Panpan Li, Meng Gu, Aijun Lin* and Hequan Yao*. Synthesis of Spiropentadiene Pyrazolones by Rh(III)-Catalyzed Formal sp3 C-H Activation/Annulation. Org. Lett.2017, 19, 2829−2832. (IF: 6.56)

15. Kaifan Zhang, Xiaoying Xu, Jiuan Zheng, Hequan Yao, Yue Huang* and Aijun Lin*. [3 + 3] Cycloaddition of in Situ Formed Azaoxyallyl Cations with 2-Alkenylindoles: An Approach to Tetrahydro-beta-carbolinones. Org. Lett. 2017, 19, 2596−2599. (IF: 6.56)

16. Xuanyi Li, Chunhua Han, Hequan Yao, and Aijun Lin*. Organocatalyzed [3 + 2] Annulation of Cyclopropenones and beta-Ketoesters: An Approach to Substituted Butenolides with a Quaternary Center. Org. Lett.2017, 19, 778−781. (IF: 6.56)

17. Shang Gao,† Hao Liu,† Chi Yang, Zhiyuan Fu, Hequan Yao,* and Aijun Lin*, Accessing 1,3-Dienes via Palladium-Catalyzed Allylic Alkylation of Pronucleophiles with Skipped Enynes. Org. Lett.2017, 19, 4710−4713. (†equal contribution) (IF: 6.56)