江振洲

江振洲,研究员,药理学博士,博士生导师。

1998年参加工作,现工作于中国药科大学药物科学研究院研究院新药筛选中心(科技部国家南京新药筛选中心、江苏省药效研究与评价服务中心),任中心副主任,入选六大人才高峰高层次人才、江苏高校青蓝工程中青年学术带头人。主要从事分子药理/毒理学和毒代动力学研究,主要研究方向是药源性肝脏毒性及其分子机制,同时结合代谢动力学进行物质基础研究。主持承担国家自然科学基金面上项目4项(在研2项),在研江苏省自然基金面上项目1项,主持完成国家自然科学基金、国家中医药管理局中医药科技研究专项等其他纵向课题7项,是国家自然科学基金重大国际合作研究项目,重大新药创制中药肝毒性早期发现关键技术、中医药行业专项等多项重大纵向课题的子课题负责人或科研骨干。获山东省科技进步奖一等奖(2015),教育部科学技术进步奖二等(2014),江苏省科技进步一等奖(2006)。已发表SCI文章157篇,其中一作或通讯作者SCI论文76篇,被引2600余次,h-index27。参与编写《雷公藤研究》。任江苏省药理学会理事、药物毒理学专业委员会秘书长,中国药学会安全性评价专业委员会委员、中国毒理学会中药与天然药物毒理专业委员会委员,中国仪器仪表学会药物质量分析与过程控制分会常务理事,中国中西医结合学会中西医结合雷公藤研究会委员,中国中西医结合学会临床药理与毒理专业委员会委员、中国医疗保健国际交流促进会中药学会委员江苏省药物研究与开发协会化学药物专业委员会副主任委员,江苏省毒理学会理事,《Chinese Journal of Natural Medicines》青年编委等。

 

主要研究方向:

1. 免疫代谢紊乱所致的药物性肝损伤分子机制与物质基础研究

2. 罕见病杜氏肌营养不良症药物作用靶点研究  

 

联系方式:

Tel025-83271043Emailbeaglejiang@cpu.edu.cnQQ972682433

 

近年代表性论文

1.        Xu Dengqiu, Zhao Lei, Jiang Jingwei, Li Sijia, Sun Zeren, Huang Xiaofei, Li Chunjie, Wang Tao, Sun Lixin, Li Xihua*, Jiang Zhenzhou*, Zhang Luyong*. A potential therapeutic effect of catalpol in Duchenne muscular dystrophy revealed by binding with TAK1. Journal of Cachexia, Sarcopenia and Muscle. 2020.

2.        Yuan Ziqiao, Liang Peishi, Muhammad Hasnat, Yuan Zihang, Zhang Haoran, Sun Lixin, Jiang Zhenzhou*, Zhang Luyong*. A new perspective of Triptolide-associated hepatotoxicity: The relevance of NF-κB and NF-κB-mediated cellular FLICE-inhibitory protein. Acta Pharmaceutica Sinica B. 2020, 10(5): 861-877.

3.        Yu Qinwei#, Huo Jingting#, Zhang Yun, Liu Kechun, Cai Yu, Xiang Ting, Jiang Zhenzhou*, Zhang Luyong*. Tamoxifen-induced Hepatotoxicity via Lipid Accumulation and Inflammation in Zebrafish. Chemosphere. 2020, 239: 124705.

4.        Muhanad Elhafiz, Zhao Guolin, Mohammed Ismail, Xu Dengqiu, Debanjan Das, Fan Sisi, Cheng Nong, Bashir A. Youseff, Jiang Zhenzhou*, Zhang Luyong*. Imbalanced insulin substrate-1 and insulin substrate-2 signaling trigger hepatic steatosis in vitamin D deficient rats: 8-methoxypsoralen, a vitamin D receptor ligand with a promising anti-steatotic action. BBA - Molecular and Cell Biology of Lipids. 2020, 1865(158657): 1-13

5.        Xu Dengqiu#, Jiang Zhenzhou#, Sun Zeren, Wang Lu, Zhao Guolin, Hozeifa M. Hassan, Fan Sisi, Zhou Wang, Han Shuangshuang, Zhang Luyong*, Wang Tao*. Mitochondrial Dysfunction and Inhibition of Myoblast Differentiation in Mice with High-fat diet-induced Pre-Diabetes. Journal of Cellular Physiology. 2019, 234(5): 7510-7523.

6.        Yang Tingting, Ghulam Jilany Khan, Wu Ziteng, Wang Xue, Zhang Luyong*, Jiang Zhenzhou*. Bile acid homeostasis paradigm and its connotation with cholestatic liver diseases. Drug Discovery Today. 2019, 24(1): 112-128.

7.        Muhammad Hasnat, Yuan Ziqiao, Muhammad Naveed, Asifullah Khan, Faisal Raza, Xu Dengqiu, Aftab Ullah, Sun Linxin, Zhang Luyong*, Jiang Zhenzhou*. Drp1 associated mitochondrial dysfunction and mitochondrial autophagy: A novel mechanism in triptolide-induced hepatotoxicity. Cell Biology and Toxicology. 2019, 35(3): 267-280.

8.        Yuan Ziqiao, Muhammad Hasnat, Liang Peishi, Yuan Zihang, Zhang Haoran, Sun Lixin,  Zhang Luyong*, Jiang Zhenzhou*. The role of inflammasome activation in Triptolide-induced acute liver toxicity. International Immunopharmacology.  2019, 75: 105754

9.        Xu Dengqiu#, Jiang Zhenzhou#, Sun Zeren, Wang Lu, Zhao Guolin, Hozeifa M. Hassan, Fan Sisi, Zhou Wang, Han Shuangshuang, Zhang Luyong*, Wang Tao*.Mitochondrial Dysfunction and Inhibition of Myoblast Differentiation in Mice with High-fat diet-induced Pre-Diabetes. Journal of Cellular Physiology. 2019, 234(5): 7510-7523

10.    Yuan Ziqiao, Zhang Haoran, Muhammad Hasnat, Ding Jiaxin, Chen Xi, Liang Peishi, Sun Lixin, Zhang Luyong*, Jiang Zhenzhou*. A new perspective of triptolide-associated hepatotoxicity: Liver hypersensitivity upon LPS stimulation. Toxicology. 2019, 414: 45-56

11.    Yu Qinwei, Jiang Zhenzhou*, Zhang Luyong*. Bile acid Regulation: A Novel Therapeutic Strategy in Non-Alcoholic Fatty Liver Disease. Pharmacology & Therapeutics. 2018, 190:81-90.

12.    Li Xiaojiaoyang, Liu Runping, Zhang Luyong, Jiang Zhenzhou*. The emerging role of AMP-activated protein kinase in cholestatic liver diseases. Pharmacological Research. 2017, 125: 105-113

13.    Yang Tingting, Mei Huifang, Xu Dengqiu, Zhou Wang, Zhu Xiaoyu, Sun Lixin, Huang Xin, Wang Xue, Shu Ting, Liu Jia, Ding Jiaxin, Hozeifa M. Hassan, Zhang Luyong*, Jiang Zhenzhou*. Early indications of ANIT-induced cholestatic liver injury: alteration of hepatocyte polarization and bile acid homeostasis. Food and Chemical Toxicology. 2017, 110:1-12

14.    Yang Tingting, Shu Ting, Liu Guanlan, Mei Huifang, Zhu Xiaoyu, Huang Xin, Zhang Luyong, Jiang Zhenzhou*. Quantitative profiling of 19 bile acids in rat plasma, liver, bile and different intestinal section contents to investigate bile acid homeostasis and the application of temporal variation of endogenous bile acids. Journal of Steroid Biochemistry & Molecular Biology. 2017, 172:69-78

15.    Li Xiaojiaoyang, Liu Runping, Luo Lan, Yu Linxi, Chen Xin, Sun Lixin, Wang Tao, Phillip B. Hylemon, Zhou Huiping*, Jiang Zhenzhou*, Zhang Luyong*. Role of AMPactivated protein kinase α1 in 17α-ethinylestradiolinduced cholestasis in rats. Archives of Toxicology. 2017, 91:481-494