陈彩萍

陈彩萍,博士,副研究员,硕士生导师。2008年获南京师范大学生物学(国家理科基地)学士学位,2014年获南京大学生物学博士学位。2015年始任职于中国药科大学药物科学研究院新药研究中心。主持国家自然科学基金青年项目、中央高校基本科研业务费专项重点项目,参与国家自然科学基金面上项目、重大研究计划等。以通讯(共通)/第一(共一)作者发表科研论文11篇,其中SCI论文10篇,申请专利4项。

研究方向:肿瘤及代谢性疾病的药理学及新药发现研究。

联系方式:caiping.chen@cpu.edu.cn;ccp1144@163.com

代表性论文:

  1. Geng Sun#, Yanping You#, Haobin Li, Yalong Cheng, Ming Qian, Xinyu Zhou, Haoliang Yuan, Qing-Long Xu, Liang Dai, Pengfei Wang, Keguang Cheng, Xiaoan Wen*, Caiping Chen*. Discovery of AdipoRon analogues as novel AMPK activators without inhibiting mitochondrial complex I. Eur J Med Chem. 2020 Aug 15;200:112466. (IF: 5.572)

  2. Minglei Li#, Shengjie Liu#, Hui Chen#, Xinyu Zhou, Jin Zhou, Shuxi Zhou Haoliang Yuan, Qing-Long Xu, Jun Liu, Keguang Cheng, Hongbin Sun, Yue Wang, Caiping Chen*, Xiaoan Wen*.N-benzylpiperidinol derivatives as novel USP7 inhibitors: Structure-activity relationships and X-ray crystallographic studies.Eur J Med Chem. 2020 Aug 1;199:112279. (IF: 5.572)

  3. Chen CP#, Chen K#, Feng Z, Wen X, Sun H*. Synergistic antitumor activity of artesunate and HDAC inhibitors through elevating heme synthesis via synergistic upregulation of ALAS1 expression. Acta Pharm Sin B. 2019, 9(5): 937-951. (IF: 5.808) (外封文章)

  4. Li EQ#, Zhao W#, Zhang C#, Qin LZ, Liu SJ, Feng ZQ, Wen X*,Chen CP*. Synthesis and anti-cancer activity of ND-646 and its derivatives as acetyl-CoA carboxylase 1 inhibitors. Eur J Pharm Sci. 2019 Sep 1;137:105010. (IF: 3.532)

  5. Chen CP#, Sang Y#, Liu L#, Feng ZQ, Liang Z*, Pei X*. THAP7 promotes cell proliferation by regulating the G1/S phase transition via epigenetically silencing p21 in lung adenocarcinoma. Onco Targets Ther. 2019 Jul 12;12:5651-5660. (IF: 3.046)

  6. Huang Y#, Sun G#, Wang P, Shi R, Zhang Y, Wen X, Sun H*, Chen C*. Synthesis and biological evaluation of Complex I inhibitor R419 and its derivatives as anticancer agents in HepG2 cells. Bioorg Med Chem Lett.2018; 28 (17), 2957-2960. (IF: 2.448)

  7. Luo HQ#, Shen J#, Chen CP#, Ma X, Lin C, Ouyang Q, Xuan CX, Liu J, Sun HB, Liu J*. Lipid-lowering effects of oleanolic acid in hyperlipidemic patients.Chin J Nat Med. 2018 May;16(5):339-346. (IF: 1.991)

  8. Song Z#, Chen CP#, Liu J, Wen X, Sun H*, Yuan H*. Design, synthesis, and biological evaluation of (2E)-(2-oxo-1, 2-dihydro-3H-indol-3-ylidene)acetate derivatives as anti-proliferative agents through ROS-induced cell apoptosis. Eur J Med Chem. 2016 Nov 29; 124:809-819. (IF: 4.519)

  9. Chen C-P, Chen X, Qiao Y-N, Wang P, He W-Q, Zhang C-H, Zhao W, Gao Y-Q, Chen C, Tao T, Sun J, Wang Y, Gao N, Kamm KE, Stull JT, and Zhu M-S*. In vivo roles for myosin phosphatase targeting subunit-1 phosphorylation sites T694 and T852 in bladder smooth muscle contraction. J Physiol. 2015 Feb 1;593(3):681-700. (IF:5.037) (获亮点报道)

  10. Holopainen T#, Huang H#, Chen C#, Kim KE, Zhang L, Zhou F, Han W, Li C, Yu J, Wu J, Koh GY, Alitalo K, He Y*. Angiopoietin-1 overexpression modulates vascular endothelium to facilitate tumor cell dissemination and metastasis establishment. Cancer Res. 2009, 69(11):4656-64. (IF:7.543)