叶慧

  

叶慧,女,中国药科大学兴药青创学者(2020-2024),现任副研究员、博士生及硕士生导师。2008年于四川大学获得本科学士学位,2013年获得美国威斯康星大学麦迪逊分校药学院博士学位。获得江苏省六大人才高峰、江苏省科协青年人才托举工程、江苏省双创博士的资助,主持国自然面上项目、青年项目、江苏省优秀青年项目、国家科技重点专项子任务、江苏省自然青年项目、教育部留学回国人员资助项目等科研项目,参与多项重大新药创制专项及重点研发计划。目前担任中国药理学会药代动力学委员会青年委员、江苏省药理学会理事及青年委员会秘书长、国际女性质谱学者协会Females in MS (FeMS)联络委员会会长。

研究聚焦组学驱动的小分子-靶标蛋白互作发现,包括:

1)建立国际领先的代谢-蛋白多组学前沿技术,发现疾病状态下紊乱的内源性代谢物的结合靶标蛋白,阐明其调控模式,发现治疗靶点蛋白;

2)基于化学蛋白质组学与分子生物学,发现临床具有确切疗效的天然药物如水飞蓟宾等发挥保肝作用的靶标,阐明天然药物的药效机制,激发针对靶标的化合物设计和改造;

3)基于长期在多肽及蛋白领域的丰富研究经验,开展生物药物的细胞药代动力学研究,监控生物药在靶细胞内与靶点的结合,描述其活性形式及代谢过程,指导创新生物药物的设计、优化及评价。

迄今在生物和分析化学权威期刊Redox BiolAPSBAnal ChemMol Cell Proteomics等以一作/通讯共发表SCI文章30余篇。申请人曾参加ASMSNeurosciencePittConBCEIA等多个国际学术会议作特邀及展板报告,并受邀成为Nature CommunMass Spectrom RevAnal ChemAnal Chim ActaSCI期刊的审稿人。

代表性研究工作如下:

•Shao C, Lu W, Du Y, Yan W, Bao Q, Tian Y, Wang G, Ye H*, Hao H*. Cytosolic ME1 integrated with mitochondrial IDH2 supports tumor growth and metastasis. Redox Biol. 2020; 36:101685. 抗肿瘤代谢双靶标的发现(IF=11.799

•Zhu Y‡, Wan N‡, Shan X, Deng G, Xu Q, Ye H*, Sun Y*. Celastrol targets adenylyl cyclase-associated protein 1 to reduce macrophages-mediated inflammation and ameliorates high fat diet-induced metabolic syndrome in mice. Acta Pharmaceutica Sinica B. 2021; 11(5):1200-1212 . 抗炎天然药物靶标发现(IF=11.413

•Shao C, Lu W, Hao H*, Ye H*. Functional Metabolomics and Chemoproteomics Approaches Reveal Novel Metabolic Targets for Anticancer Therapy. Advances in experimental medicine and biology. 2021; 1280:131-147. 专著

•Sang H‡ , Liu Jl‡ , Zhou F, Zhang XF, Zhang JW, Liu YZ, Wang GJ*, Ye H*. Target-responsive subcellular catabolism analysis for early-stage antibody‒drug conjugates screening and assessment. Acta Pharmaceutica Sinica B. 2021;Doi: https://doi.org/10.1016/j.apsb. 2021.05.024. 抗体偶联药物评价新技术(IF=11.413

•Tian Y‡, Wan N‡, Ding M, Shao C, Wang N, Bao QY, Lu WJ, Hu HY, Sun HY, Yang CX, Zhou K, Chen S, Wang GJ, Ye, H*, Hao, HP*. Chemoproteomics Maps Glycolytic Targetome in Cancer Cells. bioRxiv. 2020.11.18.387670.

•Lu G, Xu X, Li G, Sun H, Wang N, Zhu Y, Wan N, Shi Y, Wang G, Li L, Hao H, Ye H. Subresidue-Resolution Footprinting of Ligand-Protein Interactions by Carbene Chemistry and Ion Mobility-Mass Spectrometry. Anal Chem. 2020; 92(1):947-956.

结构质谱突破之亚残基水平蛋白印迹技术(IF=6.986

•Shao C‡, Lu W‡, Wan N‡, Wu M‡, Bao Q, Tian Y, Lu G, Wang N, Hao H, Ye H. Integrative Omics Analysis Revealed that Metabolic Intervention Combined with Metronomic Chemotherapy Selectively Kills Cancer Cells. J Proteome Res. 2019; 18(6):2643-2653. 代谢辅助化疗药物治疗(IF=4.074

•Zheng Q‡, Tian Y‡, Ruan X, Chen H, Wu X, Xu X, Wang G, Hao H*, Ye H*. Probing specific ligand-protein interactions by native-denatured exchange mass spectrometry. Anal Chim Acta. 2018; 1036:58-65. 基于质谱的配体靶标筛选技术(IF=5.256

•Li Q‡, Cao L‡, Tian Y, Zhang P, Ding C, Lu W, Jia C, Shao C, Liu W, Wang D, Ye H*, Hao H*. Butyrate Suppresses the Proliferation of Colorectal Cancer Cells via Targeting Pyruvate Kinase M2 and Metabolic Reprogramming. Mol Cell Proteomics. 2018; 17(8):1531-1545. 肠道菌群代谢产物靶标发现(IF=4.828

•Ye H‡, Wang J‡, Tian Z, Ma F, Dowell J, Bremer Q, Lu G, Baldo B*, Li L*. Quantitative Mass Spectrometry Reveals Food Intake-Induced Neuropeptide Level Changes in Rat Brain: Functional Assessment of Selected Neuropeptides as Feeding Regulators. Mol Cell Proteomics. 2017; 16(11):1922-1937. 治疗厌食症的功能神经肽发现(IF=5.236

•Wang L‡, Ye H‡, Sun D, Meng T, Cao L, Wu M, Zhao M, Wang Y, Chen B, Xu X, Wang G*, Hao H*. Metabolic Pathway Extension Approach for Metabolomic Biomarker Identification. Anal Chem. 2017; 89(2):1229-1237. 基于质谱的全新结构代谢物发现(IF=6.042

•Ye H, Gemperline E, Venkateshwaran M, Chen R, Delaux PM, Howes-Podoll M, Ané JM, Li L*. MALDI mass spectrometry-assisted molecular imaging of metabolites during nitrogen fixation in the Medicago truncatula-Sinorhizobium meliloti symbiosis. Plant J. 2013; 75(1):130-145. 质谱成像解密细菌-植物共生体系代谢物分布(IF=6.815

叶慧课题组是江苏省药物代谢动力学重点实验室王广基院士和郝海平教授课题组的核心组成单元,课题组具有国际领先的质谱和分子生物学研究平台。




欢迎有志于掌握生物质谱及组学利器,探索生物医药发现的同学加入研究团队!

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