叶慧

叶慧,女,博士,现任中国药科大学副研究员、博导。2008年于四川大学获得本科学士学位,2013年获得美国威斯康星大学麦迪逊分校药学院博士学位。获得江苏省优秀青年和江苏省双创博士项目的资助,主持国自然面上、青年、省自然青年、教育部留学回国人员等科研项目。

目前研究方向主要基于代谢-蛋白组学前沿技术,开发小分子-蛋白互作发现新策略,结合native ChemoproteomicsNative Denatured Exchange电离及卡宾探针标记手段等,发现代谢物/天然药物的结合蛋白,阐明其精细作用模式;结合分子生物学手段,阐明临床具有确切疗效的代谢物/天然药物对代谢过程的调控机制。并基于长期在多肽及蛋白领域的丰富研究经验,开展了生物药物的细胞药代动力学研究,精确描述生物药在靶细胞内的活性形式及代谢过程,指导创新生物药物的改造、筛选及评价。迄今在分析化学和组学权威期刊Anal. Chem.Mol. Cell. ProteomicsAnal. Chim. Acta及生物学期刊Plant J.Cell Death Dis.等以一作/通讯共发表SCI文章近30篇。申请人曾参加 ASMSNeurosciencePittConBCEIA等多个国际学术会议作特邀及展板报告,并受邀成为Anal. Chim. ActaChinese Chem. LettAnal. MethodsSCI期刊的审稿人。

欢迎有志于从事组学技术开发及其在新药研发中的探索的同学加入研究团队!

Email:cpuyehui@cpu.edu.cn

代表性论著

1. Qingran Li, Lijuan Cao, Yang Tian, Pei Zhang, Chujie Ding, Wenjie Lu, Chenxi Jia, Chang Shao, Wenyue Liu, Dong Wang, Hui Ye*, Haiping Hao*. Butyrate Suppresses the Proliferation of Colorectal Cancer Cells via Targeting Pyruvate Kinase M2 and Metabolic Reprogramming.Mol Cell Proteomics. 2018 May 8. pii: mcp.RA118.000752.

2. Hui Ye‡, Jingxin Wang‡, Zichuan Tian, James Dowell, Quentin Bremer, Gaoyuan Lu, Brian Baldo*, Lingjun Li*. Quantitative Mass Spectrometry Reveals Food Intake-Induced Neuropeptide Level Changes in Rat Brain: Functional Assessment of Selected Neuropeptides as Feeding Regulators. Mol Cell Proteomics. 2017 Nov; 16(11):1922-1937 (Cover article).

3. Mengqiu Wu‡, Hui Ye‡, Zhiyuan Tang‡, Chang Shao, Gaoyuan Lu, Baoqiang Chen, Yuyu Yang, Guangji Wang*, Haiping Hao*. p53 dynamics orchestrates with binding affinity to target genes for cell fate decision. Cell Death Dis. 2017 Oct 19;8(10):e3130.

4. Lin Wang ‡Hui Ye Di SunTuo MengLijuan CaoMengqiu WuMin ZhaoYun WangBaoqiang ChenXiaowei XuGuangji Wang *Haiping Hao**. A metabolic pathway extension approach for metabolomic biomarker identification.Anal Chem2017, 89(2):1229-1237

5. Hua SangGaoyuan LuYazhong LiuQiyue HuWeifeng XingDongbing CuiFang ZhouJingwei ZhangHaiping HaoGuangji Wang*Hui Ye**. Conjugation site analysis of antibody-drug-conjugates (ADCs) by signature ion fingerprinting and normalized area quantitation approach using nano-liquid chromatography coupled to high resolution mass spectrometry.Anal Chim Acta2017.2.2222955):67~78

6. Mengqiu Wu ‡, Hui Ye ‡, Chang Shao, Xiao Zheng, Qingran Li, Lin Wang, Min Zhao, Gaoyuan Lu, Baoqiang Chen, Jun Zhang, Yun Wang, Guangji Wang*, Haiping Hao**. Metabolomics-proteomics combined approach identifies differential metabolism-associated molecular events between senescence and apoptosis. J Proteome Res. 2017 May 10.

7. Ye H‡, Wang L‡, Zhu L, Sun D, Luo X, Wang H, Wang G, Hao H. Stepped collisional energy MSAll: an analytical approach for optimal MS/MS acquisition of complex mixture with diverse physicochemical properties. J Mass Spectrom., 2016, 51(5):328-41.

8. Ye H‡, Zhu L‡, Wang L, Liu H, Zhang J, Wu M, Wang G*, Hao H*. Stepped MSAll Relied Transition (SMART): an approach to rapidly determine optimal multiple reaction monitoring mass spectrometry parameters for small molecules. Anal Chim Acta., 51(5):328-41.

9. Ye H, Wang J, Zhang Z, Jia C, Schmerberg C, Catherman AD, Thomas PM, Kelleher NL, Li L*. Defining the Neuropeptidome of the Spiny Lobster Panulirus interruptus Brain Using a Multidimensional Mass Spectrometry-Based Platform. J Proteome Res., 14(11):4776-91.

10. Ye H, Mandal R, Catherman A, Thomas PM, Kelleher NL, Ikonomidou C, Li L*. Top-down proteomics with mass spectrometry imaging: a pilot study towards discovery of biomarkers for neurodevelopmental disorders. PLoS One, 9(4):e92831.

11. Ye H, Wang J, Greer T, Strupat K, Li L.* Visualizing neurotransmitters and metabolites in the central nervous system by high resolution and high accuracy mass spectrometric imaging. ACS Chem. Neurosci., 4(7):1049-56.

12. Ye H, Gemperline E, Venkateshwaran M, Chen R, Delaux PM, Howes-Podoll M, Ané JM, Li L.* MALDI mass spectrometry-assisted molecular imaging of metabolites during nitrogen fixation in the Medicago truncatula-Sinorhizobium meliloti symbiosis. Plant J., 75(1):130-45.