周长林

周长林(博士/教授/博导),中国药科大学,生命科学与技术学院,微生物学教研室;
联系方法:
江苏省南京市中央路童家巷24号,邮编:210009;
Tel. & Fax: 025-83271323; E-mail: cl_zhou@cpu.edu.cn
1、简历
周长林,男,1964年1月生,1986、1989和1997年于华东理工大学生物工程专业分别获学士、硕士和博士学位,1999.4-2000.3年日本近畿大学药学部访问学者,2004.12-2005.11年美国Providence College生物系博士后。现为中国药科大学生命科学与技术学院副院长、教授、博士生导师,国家药品食品监督管理局化妆品评审专家、卫生部第六届兽药评审专家,国家国际科技合作专项项目、中国博士后科学基金评审专家,担任中国微生物学会酶工程专业委员会委员、江苏省第九届生物化学和分子生物学学会常务理事, 《中国药科大学学报》、《中国生化药物杂志》、《药物生物技术》、《药学与临床研究》杂志编委。2008年被评为江苏省“青蓝工程”中青年学术带头人。长期从事微生物与生化药学教学和研究工作,主要研究方向为抗感染药物药效及其机理、微生物代谢调控与生物制药。主持多项国家、省部级和横向科研课题。至今发表研究论文100余篇,其中SCI收录38篇,申请多项发明专利(授权12项),主编出版教材4部。
2、研究方向
抗感染药物药效及机理、微生物代谢调控的分子机制和生物制药。
3、近年来发表研究论文(SCI)
(1) Lingman Ma, Yanrong Wang, Mengxiao Wang, Yuwei Tian, Wei Kang, Hanhan Liu, Hui Wang, Jie Dou*, Changlin Zhou*. Effective antimicrobial activity of Cbf-14, derived from a cathelin-like domain, against penicillin-resistant bacteria. Biomaterials (2016). 87: 32-45 (IF 8.387)
(2) Jie Yu, Dechuan Wang, Jing Jin, Jun Xu, Mengwei Li, Hui Wang, Jie Dou, Changlin Zhou*, Antiviral activity of SA-2 against influenza A virus in vitro/vivo and its inhibition of RNA polymerase. Antiviral Research. (2016), 127: 68-78 (IF 4.909)
(3) Mengyun Ke, Hui Wang, Yiran Zhou, Jingwen Li, Yang Liu, Min Zhang, Jie Dou, Tao Xi, Baiyong Shen*, Changlin Zhou*. SEP enhanced the antitumor activity of 5-fluorouracil by up-regulating NKG2D/MICA and reversed immune suppression via inhibiting ROS and caspase-3 in mice. Oncotarget (2016), DOI: 10.18632/oncotarget.10375 (IF 5.008)
(4) Hailong Chen, Zhilai Wang, Haibo Cai, Changlin Zhou*. Progress in the Microbial Production of S-Adenosyl-L-methionine. World J Microbiol Biotechnol (2016), DOI: 10.1007/s11274-016-2102-8 (IF 1.532)
(5) Bo Li, Wei Kang, Hanhan Liu, Yanrong Wang, Changzhong Yu, Xinyi Zhu, Jie Dou, Haibo Cai, Changlin Zhou*. The antimicrobial activity of Cbf-K16 against MRSA was enhanced by β-lactam antibiotics through cell wall non-integrity. Archives of Pharmacal Research (2016), DOI 10.1007/s12272-016-0769-x (IF 2.490)
(6) Hailong Chen, Jie Dou, Yang Yang, Baohui Li, Changlin Zhou*. Elevated intracellular acetyl-CoA availability by acs2 overexpression and mls1 deletion combined with metK1 introduction enhanced SAM accumulation in Saccharomyces cerevisiae. Biochemical Engineering Journal (2016), 107: 26-34. (IF 2.463)
(7) Hailong Chen, Zhou Wang, Zhilai Wang, Jie Dou, Changlin Zhou*. Improving methionine and ATP availability by MET6 and SAM2 co-expression combined with sodium citrate feeding enhanced SAM accumulation in Saccharomyces cerevisiae. World J Microbiol Biotechnol (2016), 32:56 (IF 1.532)
(8) Mengyun Ke, Hui Wang, Min Zhang, Yuwei Tian, Yizhou Wang, Bing Li, Jie Yu, Jie Dou, Tao Xi, Changlin Zhou*. The anti-lung cancer activity of SEP is mediated by the activation and cytotoxicity of NK cells via TLR2/4 in vivo. Biochemical Pharmacology, 2014, 89: 119-130 (IF 5.009)
(9) Yang Yang, Chao Yuan, Jie Dou, Xiaorong Han, Hui Wang, Hongqing Fang, Changlin Zhou*. Recombinant expression of glpK and glpD genes improves the accumulation of shikimic acid in E. coli grown on glycerol. World J Microbiol Biotechnol (2014) 30: 3263-3272 (IF 1.779)
(10) Yue Ding, Jie Dou, Zaijin Teng, Jie Yu, Tingting Wang, Na Lu, Hui Wang, Changlin Zhou*. Antiviral activity of baicalin against influenza A (H1N1/ H3N2) virus in cell culture and in mice and its inhibition of neuraminidase. Arch Virol (2014), 159 (12): 3269-3278 (IF 2.39)
(11) Jing Wang, Bing Li, Yang Li, Jie Dou, Qingru Hao, Yuwei Tian, Hui Wang, Changlin Zhou*. BF-30 effectively inhibits ciprofloxacin-resistant bacteria in vitro and in a rat model of vaginosis. Arch Pharm Res. 2014, 37(7): 927-936 (IF 2.046)
(12) Yuwei Tian, Hui Wang, Bing Li, Mengyun Ke, Jing Wang, Jie Dou, Changlin Zhou*. The cathelicidin-BF Lys16 mutant Cbf-K16 selectively inhibits non-small cell lung cancer proliferation in vitro. Oncol Rep. 2013; 30: 2502-2510 (IF 2.297)
(13) Hui Wang, Mengyun Ke, Yuwei Tian, Jing Wang, Bing Li, Yizhou Wang, Jie Dou, Changlin Zhou*. BF-30 selectively inhibits melanoma cell proliferation via cytoplasmic membrane permeabilization and DNA-binding in vitro and in B16F10-bearing mice. European Journal of Pharmacology. 2013; 707: 1-10 (IF 2.592)
(14) Qingru Hao, Hui Wang, Jing Wang, Jie Dou, Min Zhang, Weidong Zhoua, Changlin Zhou*. Effective antimicrobial activity of Cbf-K16 and Cbf-A7A13 against NDM-1-carrying Escherichia coli by DNA binding after penetrating the cytoplasmic membrane in vitro. J. Pept. Sci. 2013; 19: 173–180 (IF 2.071)
(15) Kai Chen, Jie Dou, Shirui Tang, Yishun Yang, Hui Wang, Hongqing Fang, Changlin Zhou*. Deletion of the aroK gene is essential for high shikimic acid accumulation through the shikimate pathway in E. coli. Bioresource Technology, 2012 May 29; 119C: 141-147 (IF 4.75)
(16) Lili Chen, Jie Dou, Zhenzhen Su, Huimin Zhou, Hui Wang, Weidong Zhou, Qinglong Guo, Changlin Zhou*. Synergistic activity of baicalein with ribavirin against influenza A (H1N1) virus infections in cell culture and in mice. Antiviral Research. 2011, 91(3): 314-320 (IF 4.301)