周长林

1、简历

周长林,男,19641月生,198619891997年于华东理工大学生物工程专业分别获学士、硕士和博士学位,1999.4-2000.3年日本近畿大学药学部访问学者,2004.12-2005.11年美国Providence College生物系博士后。现为中国药科大学生命科学与技术学院教授、博士生导师,国家新药评审专家,国家国际科技合作专项项目、中国博士后科学基金评审专家,江苏省生物工程学会副理事长,江苏省第九届生物化学和分子生物学学会常务理事《中国药科大学学报》、《中国生化药物杂志》、《药物生物技术》杂志编委。2008年被评为江苏省青蓝工程中青年学术带头人。长期从事微生物与生化药学教学和研究工作,主要研究方向为抗感染药物药效及其机理、微生物代谢调控与药物生物合成。主持多项国家、省部级和横向科研课题。至今发表研究论文100余篇,其中SCI收录45篇,申请多项发明专利(授权12项),主编出版教材4部。

2、研究方向

抗感染药物药效及机理、微生物代谢调控与药物生物合成。

3、近年来发表研究论文(SCI

1Zhou Wang, Lingman Ma, Mengqi Su, Yiran Zhou, Ke Mao, Chengqin Li, Guangyong Peng, Changlin Zhou*, Baiyong Shen* and Jie Dou*. Baicalin induces cellular senescence in human colon cancer cells via upregulation of DEPP and the activation of Ras/Raf/MEK/ERK signaling. Cell Death and Disease (2018) 9:217, DOI 10.1038/s41419-017-0223-0 (IF 5.965)

2Yu C, Wei S, Han X, Liu H, Wang M, Jiang M, Guo M, Dou J, Zhou C*, Ma L*. Effective inhibition of Cbf-14 against Cryptococcus neoformans infection in mice and its related anti-inflammatory activity. Fungal Genet Biol. 2018 Jan;110:38-47. doi: 10.1016/j.fgb.2017.11.008. Epub 2017 Dec 6 (IF 3.072)

3Jing Jin, Shuo chen Dechuan Wang, Yuanjin Chen, Yuxu Wang, Ming Guo, Changlin Zhou*, Jie Dou*. Oroxylin A suppresses influenza A virus repplication correlating with neuraminidase inhibition and induction of IFNs. Biomedicine & Pharmacotherapy. (2017), 97:385-394

4Wei Kang1, Hanhan Liu1, Lingman Ma, Mengxiao Wang, Shanshan Wei, Pengbo Sun, Meiling Jiang, Min Guo, Changlin Zhou*, Jou Dou*. Effective antimicrobial activity of a peptide mutant Cbf-14-2 against penicillin-resistant bacteria based on its unnatural amino acids. European Journal of Pharmaceutical Science. (2017), 105:169-177 (IF 3.756)

5Xin Xie, Yiran Zhou, Xue Wang, Jian Guo, Jingwen Li, Hongye Fan, Jie Dou, Baiyong Shenb*, Changlin Zhou*. Enhanced antitumor activity of gemcitabine bypolysaccharide-induced NK cell activation and immune cytotoxicityreduction in vitro/vivo. Carbohydrate Polymers, 173 (2017) 360–371 (IF 4.811)

6Wei Kang, Hanhan Liu, Lingman Ma, Mengxiao Wang, Shanshan Wei , Pengbo Sun, Meiling Jiang, Min Guo, Changlin Zhou*, Jie Dou*. Effective antimicrobial activity of a peptide mutant Cbf-14-2 against penicillin-resistant bacteria based on its unnatural amino acids. European Journal of Pharmaceutical SciencesEuropean Journal of Pharmaceutical Sciences, 105 (2017) 169177 (IF 3.773)

7LI Jing-Wen, LIU Yang, LI Bao-Hui, Wang Yue-Yang, WANG Hui, ZHOU Chang-Lin*. A polysaccharide component purified from Radix Adenophorae promotes cell activation and pro-inflammatory cytokine production of murine RAW264.7 macrophages. Chinese Journal of Natural Medicines. 2016, 14(5): 0370-0376 (IF 1.382)

8Mengyun Ke, Hui Wang, Yiran Zhou, Jingwen Li, Yang Liu, Min Zhang, Jie Dou, Tao Xi, Baiyong Shen*, Changlin Zhou*. SEP enhanced the antitumor activity of 5-fluorouracil by up-regulating NKG2D/MICA and reversed immune suppression via inhibiting ROS and caspase-3 in mice. Oncotarget(2016), DOI: 10.18632/oncotarget.10375 (IF 5.008)

9Hailong Chen, Zhilai Wang, Haibo Cai, Changlin Zhou*. Progress in the Microbial Production of S-Adenosyl-L-methionine. World J Microbiol Biotechnol (2016), 32(9), 1-8 (IF 1.532)

10Bo Li, Wei Kang,Hanhan Liu, Yanrong Wang, Changzhong Yu, Xinyi Zhu, Jie Dou, Haibo Cai, Changlin Zhou*. The antimicrobial activity of Cbf-K16 against MRSA was enhanced by β-lactam antibiotics through cell wall non-integrity. Archives of Pharmacal Research (2016), DOI 10.1007/s12272-016-0769-x (IF 2.490)

11Lingman Ma, Yanrong Wang, Mengxiao Wang, Yuwei Tian, Wei Kang, Hanhan Liu, Hui Wang, Jie Dou*Changlin Zhou*. Effective antimicrobial activity of Cbf-14, derived from a cathelin-like domain, against penicillin-resistant bacteria. Biomaterials (2016). 87: 32-45 (IF 8.387)

12Jie Yu, Dechuan Wang, Jing Jin, Jun Xu, Mengwei Li, Hui Wang, Jie Dou, Changlin Zhou*, Antiviral activity of SA-2 against influenza A virus in vitro/vivo and its inhibition of RNA polymerase. Antiviral Research. (2016), 127: 68-78 (IF 4.909)

13Hailong Chen, Jie Dou, Yang Yang, Baohui Li, Changlin Zhou*. Elevated intracellular acetyl-CoA availability by acs2 overexpression and mls1 deletion combined with metK1 introduction enhanced SAM accumulation in Saccharomyces cerevisiaeBiochemical Engineering Journal (2016), 107: 26-34. (IF 2.463)

14Hailong Chen, Zhou Wang, Zhilai Wang, Jie Dou, Changlin Zhou*. Improving methionine and ATP availability by MET6 and SAM2 co-expression combined with sodium citrate feeding enhanced SAM accumulation in Saccharomyces cerevisiae. World J Microbiol Biotechnol (2016), 32:56 (IF 1.532)

15Yang Yang, Chao Yuan, Jie Dou, Xiaorong Han, Hui Wang, Hongqing Fang, Changlin Zhou*. Recombinant expression of glpK and glpD genes improves the accumulation of shikimic acid in E. coli grown on glycerol. World J Microbiol Biotechnol (2014), 30: 3263-3272 (IF 1.779)

16Yue Ding, Jie Dou, Zaijin Teng, Jie Yu, Tingting Wang, Na Lu, Hui Wang, Changlin Zhou*. Antiviral activity of baicalin against influenza A (H1N1/ H3N2) virus in cell culture and in mice and its inhibition of neuraminidase. Arch Virol (2014), 159 (12): 3269-3278 (IF 2.39)

17Wang Y, Wang W, Lv Y, Zheng W, Mi Z, Pei G, An X, Xu X, Han C, Liu J, Zhou C*, Tong Y*. Characterization and complete genome sequence analysis of novel bacteriophage IME-EFm1 infecting Enterococcus faecium.J Gen Virol. 2014 Nov; 95(Pt 11): 2565-75 (IF 3.183)

18Mengyun Ke, Hui Wang, Min Zhang, Yuwei Tian, Yizhou Wang, Bing Li, Jie Yu, Jie Dou, Tao Xi, Changlin Zhou*. The anti-lung cancer activity of SEP is mediated by the activation and cytotoxicity of NK cells via TLR2/4 in vivoBiochemical Pharmacology, 2014, 89: 119-130 (IF 5.009)

19Jing Wang, Bing Li, Yang Li, Jie Dou, Qingru Hao, Yuwei Tian, Hui Wang, Changlin Zhou*. BF-30 effectively inhibits ciprofloxacin-resistant bacteria in vitro and in a rat model of vaginosis. Arch Pharm Res. 2014, 37(7): 927-936 (IF 2.046)

4、联系方式

中国药科大学,生命科学与技术学院,微生物学教研室;

江苏省南京市中央路童家巷24号,邮编:210009

Tel.: 025-8327-1323Fax: 025-8327-1249

E-mail: cl_zhou@cpu.edu.cn