金亮

金亮, 博士,教授,江苏省特聘教授,博士生导师。20066月于中国药科大学获博士学位,同年8月留校任讲师;20105月晋升为副教授,同年7月赴美国国家医学中心(City of Hope)从事博士后研究,主要研究方向为胰腺干/祖细胞的分离、鉴定及定向分化。20145月返回中国药科大学。近5年主持及参与国家863计划项目,国家科技新药创制重大专项,国家自然科学基金项目等多项。发表SCI收录研究论文30余篇,授权专利5项。

研究方向:

1 胰腺干/祖细胞在糖尿病治疗中的应用及开发;

2 人脂肪源干细胞在组织损伤中的应用与开发;

3组织干细胞的正常发育、变异及肿瘤干细胞的形成机制;

4用于糖尿病治疗的多肽类药物研究与开发;

第一及通讯作者研究论文

1.Jin Liang, Wang Yu, Xiong Qiyan, Chen Qingmei, Li Jianping, Zhu Aihua, Cao Rongyue, Wu Jie, Liu Jingjing Long-lasting specific antibodies against p277 induced by mucosal administration of p277 repeat sequences carried by Hsp65 in the absence of adjuvants. Vaccine; 2007 25: 2043-2050, (IF: 3.235).

2.Liang Jin, Aihua Zhu, Yu Wang, Qingmei Chen, Qiyan Xiong, Taiming Li, Jie Wu, and Jingjing Liu*. A Th1 recognized peptide P277, when tandem repeated, induces a Th2 cytokine burst and toward effective vaccines against autoimmune diabetes in NOD mice. The journal of immunology; 2008, 180 (1): 58 – 63, (IF: 4.856).

3.Jin Liang, Zhu aihua, Wang Yu, Liu JingJing*; Enhanced immunogenicity of peptide P277 by heat shock protein HSP65 vector carrying tandem repeats of P277 to prevent type 1 diabetes in NOD mice. Experimental and Clinical Endocrinology & Diabetes; 2008, 116 (9):1-8, (IF: 1.685).

4.Jin Liang, Zhu Aihua, Wang Yu, Lu Yong Liu Jingjing*; HSP65 serves as an immunogenic carrier for a diabetogenic peptide P277 inducing anti-inflammatory immune response in NOD mice by nasal administration. Vaccine; 2010, 28: 3312-33172, (IF: 3.235).

5.Liang Jin, Tao Feng, Hung Ping Shih, Ricardo Zerda, Angela Luo, Jasper Hsu, Alborz Mahdavi, Maike Sander, David A. Tirrell, Arthur D. Riggs, and Hsun Teresa Ku*. Colony-forming cells in the adult mouse pancreas are expandable in Matrigel and form endocrine/acinar colonies in laminin hydrogel. PNAS; 2013, 110 (10): 3907-3912, (IF: 9.661).

6.Xianghui Fu, Liang Jin, Xichun Wang, Angela Luo, Junkai Hu, Xianwu Zheng, Walter M. Tsark, Arthur D. Riggs, H. Teresa Ku*. Wendong Huang; MicroRNA-26a targets ten eleven translocation enzymes and is regulated during pancreatic cell differentiation. PNAS; 2013, 110 (44): 17892-17897, (Co-first, IF: 9.661).

7.Liang Jin, Tao Feng, Ricardo Zerda, Ching-Cheng Chen, Arthur D. Riggs and Hsun Teresa Ku*; In vitro multi-lineage differentiation and self-renewal of single pancreatic colony-forming cells from adult C57Bl/6 mice; Stem Cells Dev; 2014, 23 (8): 899-909, (IF: 3.562).

8.Liang Jin,Tao Feng, Jing Chai, Nadiah Ghazalli, Dan Gao, Ricardo Zerda, Zhuo Li,Jasper Hsu, Alborz Mahdavi, David A. Tirrell, Arthur D. Riggs,and Hsun Teresa Ku*. Colony-forming progenitor cells in the postnatal mouse liver and pancreas give rise to morphologically distinct insulin-expressing colonies in 3D cultures. Rev Diabet stud; 2014, 11(1):35-50, (IF: 2.94).

9.Jin, Liang  Gao, Dan  Feng, Tao Tremblay, Jacob R. Ghazalli, Nadiah  Luo, Angela  Rawson, Jeffrey  Quijano, Janine C.  Chai, Jing  Wedeken, Lena  Hsu, Jasper LeBon, Jeanne  Walker, Stephanie Shih, Hung-Ping Mahdavi, Alborz  Tirrell, David A. Riggs, Arthur D. Ku, H. Teresa. Cells with surface expression of CD133^(high)CD71^(low) are enriched for tripotent colony-forming progenitor cells in the adult murine pancreas. Stem Cell Research; 2016, 16(1): 40-53, (IF: 3.494).

10.  Qiyan Xiong, Jiao Feng, Yu Zhang, Yunxiao Sun, Yong Lu, Taiming Li , Xiaohong Zhang, Rongyue Cao, Liang Jin*, Jie Wu*, Promotion of atherosclerosis in high cholesterol diet-fed rabbits by immunization with the P277 peptide, Immunology Letters, 2016, 170: 80–87, ( Co-corresponding author, IF: 2.860).

12. Shiping LU, Guoliang LI, Kunfeng LIU, Xue YANG, Rongyue CAO, Li Zong, Jun Long, Jie WU*, Liang JIN*, Fusion Protein His-Hsp65-6IA2P2 Prevents Type 1 diabetes Through Nasal Immunization in NOD Mice, International Immunopharmacology, 2016, 35 (6):235-242, ( Co-corresponding author, IF: 2.956).

13. Lili Shen*, Shiping Lu*, Dongcheng Huang, Guoliang Li, Kunfeng Liu, Liang Jin*Jie Wu*, A rationally designed peptide IA-2-P2 against type 1 diabetes in streptozotocin-induced diabetic mice, Diab Vasc Dis Res, 2017;14(3):184-190. (Co-corresponding author, IF: 3.417).

14. Cheng-Qiong Luo*,Lei Xing*, Peng-Fei Cui, Jian-Bin Qiao, Yu-Jing He, Bao-An Chen, Liang Jin*, Hu-Lin Jiang*, Curcumin-coordinated nanoparticles with improved stability for reactive oxygen species-responsive drug delivery in lung cancer therapy, International Journal of Nanomedicine, 2017:12 855–869( Co-corresponding author, IF: 4.300 ).

15. Zhao Y, Tang SGuo JAlahdal MCao SYang ZZhang FShen YSun MMo RZong LJin L*. Targeted delivery of doxorubicin by nano-loaded mesenchymal stem cells for lung melanoma metastases therapy, Sci Rep. 2017 Mar 17; 7: 44758. (Co-corresponding author, IF: 4.259).

16. Gao HZhao QSong ZYang ZWu YTang SAlahdal MZhang Y*, Jin L*. PGLP-1,a novel long-acting dual-function GLP-1 analog, amelioratesstreptozotocin-induced hyperglycemia and inhibits body weight loss. FASEB J. 2017 31(8):3527-3539 (Co-corresponding author, IF: 5.498).

17. Dongshen Ma, Shanshan Tang, Jing Song, Qiong Wu, Fangfang Zhang, Yun Xing, Yi Pan, Yanfeng Zhang, Jingwei Jiang*, Yubin Zhang*, Liang Jin*,  Culturing and Transcriptome Profiling of Progenitor-like Colonies Derived from Adult Mouse Pancreas. Stem Cell Research & Therapy, 20178:172-187(Co-corresponding author, IF:4.211 ).

18. Cao S, Guo J, He Y, Alahdal M, Tang S, Zhao Y, Yang Z, Gao H, Hu W, Jiang H*, Qin L*, Jin L*. Nano-loaded human umbilical cord mesenchymal stem cells as targeted carriers of doxorubicin for breast cancer therapy. Artif Cells Nanomed Biotechnol. 2018 Feb 19:1-11. (Co-corresponding author, IF: 5.605).

19. Song JMa DXing YTang SAlahdal MGuo JPan YZhang YShen YWu QLu ZJin L*. α-Ketoglutarate Promotes Pancreatic Progenitor-Like Cell Proliferation.Int J Mol Sci. 2018 Mar 22;19(4). pii: E943. doi: 10.3390/ijms19040943. (Corresponding author, IF: 3.226).

联系方式liangjin1975@cpu.edu.cn; 6238564@qq.com 025-83271152