尹莉芳

尹莉芳,女,教授,博士,博士生导师,药学院副院长,先后在中国药科大学药剂学(本科、硕士)、药代动力学(博士),北京大学(博士后)学习,2006年、2014年借调至国家食品药品监督管理局审评中心工作。
担任中国药学会药剂专业委员副主任委员,国家发改委药品价格评审专家,国家科学技术奖励办审评专家,科技部国际合作同行专家,国家食品药品监督管理局审评中心、江苏省食品药品监督管理局审评专家。
获教育部新世纪优秀人才,南京市首批321领军型科技创业人才计划重点支持,江苏省青蓝工程创新团队带头人,南京市突出贡献中青年专家,江苏省“333工程”第四批第三层次培养对象,江苏省“333工程”第五批第二层次培养对象,中国药学会-石药集团青年药剂学奖,“口服缓控释制剂的关键技术及其产业化研究” 获2009年江苏省科技进步奖二等奖(排名第一)。“缓释智能递药系统的关键技术及其应用”获得2018年江苏省科学技术奖一等奖(排名第一)
近年来主持企业项目五十余项,主持科技部重大专项、国家自然基金委、教育部、江苏省科技厅、江苏省教育厅、江苏省人才办项目十余项,在缓控释制剂、固体制剂方向产业化经验丰富,与国内外数十家企业合作,完成一类创新药西达本胺片药学研究,获得20余个新药证书或者临床批件,以第一发明人申请发明专利40余项,获得授权9项,专利权转让3项。参编药剂学、药剂学实验等教材,以第一作者或者通讯作者在ACS NanoAdvanced Science等期刊上发表高水平论文50余篇。
研究方向:药物新剂型:缓控释给药系统;纳米给药系统;药物掩味技术。
联系方式025-83271018lifangyin_@163.com


代表性论文
1.Yaqi Lv, Chaoran Xu, Xiangmei Zhao, Chenshi Lin, Xin Yang, Xiaofei Xin, Li Zhang, Chao Qin, Xiaopeng Han, Lei Yang, Wei He*,Lifang Yin*. Nanoplatform Assembled from a CD44-Targeted Prodrug and Smart Liposomes for Dual Targeting of Tumor Microenvironment and Cancer Cells. ACS Nano, 2018,12(2):1519-1536.

2.Xiaofei Xin, Chao Teng, Xiaoqing Du, Yaiqi Lv, Qingqing Xiao, Yubing Wu, Wei He*, Lifang Yin*. Drug-delivering-drug platform-mediated potent protein therapeutics via a non-endo-lysosomal route. Theranostics, 2018, 8(13):3474-3489.

3.Yaqi Lv, Xiangmei Zhao, Lidan Zhu, Sijia Li, Qingqing Xiao, Wei He*, Lifang Yin*. Targeting intracellular MMPs efficiently inhibits tumor metastasis and angiogenesis. Theranostics, 2018, 8(10):2830-2845.

4.Chao Qin, Mengmeng Wu, Siyuan Xu, Xiaowei Wang, Wenxing Shi, Yangyu Dong, Lei Yang, Wei He, Xiaopeng Han*, Lifang Yin*. Design and optimization of gastro-floating sustained-release tablet of pregabalin: in vitro and in vivo evaluation. International Journal of Pharmaceutics, 2018, 545(1-2):37-44.

5.Li Zhang, Qingqing Xiao, Yiran Wang, Chenshuang Zhang, Wei He*, Lifang Yin*. Denatured protein-coated docetaxel nanoparticles: Alterable drug state and cytosolic delivery. International Journal of Pharmaceutics, 2017, 523(1):1-14.

6.Xiaofei Xin, Xue Pei, Xin Y ang, Yaqi Lv, Li Zhang, Wei He*, Lifang Yin*. Rod-Shaped Active Drug Particles Enable Efficient and Safe Gene Delivery. Advanced Science, 2017:1700324.

7.Chao Qin, Yaqi Lv, Chaoran Xu, Jingjing Li, Lifang Yin*, Wei He*. Lipid-bilayer-coated nanogels allow for sustained release and enhanced internalization. International Journal of Pharmaceutics,2018,551(1-2):8-13.

8.Xiaofei Xin, Xiaoqing Du, Qingqing Xiao, Helena S.Azevedo, Wei He*, Lifang Yin*. Drug Nanorod-Mediated Intracellular Delivery of microRNA-101 for Self-sensitization via Autophagy Inhibition.Nano-Micro Letters,2019,11(04):453-468.

9.Xiaofei Xin, Feng Lin, Qiyue Wang, Lifang Yin*, Ram I. Mahato*. ROS-Responsive Polymeric Micelles for Triggered Simultaneous Delivery of PLK1 Inhibitor/miR-34a and Effective Synergistic Therapy in Pancreatic Cancer. ACS applied materials & interfaces,2019,11(16):14647-14659.

10Chao Teng, Zhuodong Chai, Zhongyue Yuan, Lianjie Ren, Chenshi Lin, Zhen Yan, Wei He, Chao Qin, Lei Yang, Xiaopeng Han*, Lifang Yin*.Desirable PEGylation for improving tumor selectivity of hyaluronic acid-based nanoparticles via low hepatic captured, long circulation times and CD44 receptor-mediated tumor targeting.Nanomedicine: Nanotechnology, Biology and Medicine.2020:102105.