徐晓军

                               自我简介

①本人简介
徐晓军,男,1978年8月生,中国药科大学副教授,博士生导师。
2000/09-2008/06年,海德堡大学,生物系,博士研究生,获博士学位
2000/09-2004/06年,中国科学院上海分院,生化细胞所,研究生
1996/09-2000/06年,南京大学,生物科学与技术系,本科,获学士学位
②研究方向;
基于FOXO活性以及糖尿病果蝇模型的中药复方活性组分分析
胰岛素信号通路与线粒体功能相互关系及其在天然药物活性物质筛选中的应用
Insulin/mTOR信号通路对代谢的调控机理及利用果蝇模式生物来筛选中药复方活性成分
基于PPARγ-ApoE激动成分的抗老年痴呆活性物质发现与药效
③主持科研项目情况:
1.国家自然科学基金面上项目(81274159) 基于FOXO活性以及糖尿病果蝇模型的金芪降糖片活性组分分析 
2.高等学校博士学科点专项科研基金(20120096120007)
3.新世纪优秀人才支持计划(02431004)
4.国家自然科学基金面上项目(81573637) 基于PPARγ-ApoE的酸枣仁抗阿尔茨海默症协同成分发现与作用机制研究
④近年来代表性科研成果:
1. Transketolase-like protein 1 (TKTL1) is required for rapid cell growth and full viability of human tumor cells. Xu X, Zur Hausen A, Coy JF, Löchelt M. Int J Cancer. 2009 Mar 15;124(6):1330-7.
2.   6-Shogaol induces apoptosis in human hepatocellular carcinoma cells and exhibits anti-tumor activity in vivo through endoplasmic reticulum stress.Hu R, Zhou P, Peng YB, Xu X, Ma J, Liu Q, Zhang L, Wen XD, Qi LW, Gao N, Li P.PLoS One. 2012;7(6):e39664.
3. Insulin signaling regulates fatty acid catabolism at the level of CoA activation. Xu X, Gopalacharyulu P, Seppänen-Laakso T, Ruskeepää AL, Aye CC, Carson BP, Mora S, Orešič M, Teleman AA. PLoS Genet. 2012 Jan;8(1):e1002478. doi: 10.1371/journal.pgen.1002478.
4.    Triptolide inhibits amyloid-β production and protects neural cells by inhibiting CXCR2 activity. Wang J, Shi ZQ, Xu X (通讯作者), Xin GZ, Chen J, Qi LW, Li P. J Alzheimers Dis. 2013;33(1):217-29. doi: 10.3233/JAD-2012-120841.
5.   Chemical Profiling of Jinqi Jiangtang Tablets by High-performance Liquid Chromatography Coupled with Electrospray Ionization Quadrupole Time-of-flight Tandem Mass Spectrometry  Sun S, XIE ZS, LIU EH, YAN YT, XU X (通讯作者), LI P. Chinese Journal of Natural Medicines.  2014 Mar;12(3):229-40.
6.  Antitumor activity of gemcitabine can be potentiated in pancreatic cancer through modulation of TLR4/NF-κB signaling by 6-shogaol. Zhou L, Qi L, Jiang L, Zhou P, Ma J, Xu X (通讯作者), Li P. AAPS J. 2014 Mar;16(2):246-57.
7.    Camptothecin and its Analogs Reduce Amyloid-β Production and Amyloid-β42-Induced IL-1β Production. Wang J, Shi ZQ, Zhang M, Xin GZ, Pang T, Zhou P, Chen J, Qi LW, Yang H, Xu X (通讯作者), Li P. J Alzheimers Dis. 2015;43(2):465-77.
8.   Dan-Qi prescription ameliorates insulin resistance through overall corrective regulation of glucose and fat metabolism. Xie Z, Loi Truong T, Zhang P, Xu F, Xu X (通讯作者), Li P. J Ethnopharmacol. 2015 Aug 22;172:70-9.
9.     Heparan sulfate D-glucosaminyl 3-O-sulfotransferase-3B1 (HS3ST3B1) promotes angiogenesis and proliferation by induction of VEGF in acute myeloid leukemia cells. Zhang L, Song K, Zhou L, Xie Z, Zhou P, Zhao Y, Han Y, Xu X(通讯作者), Li P. J Cell Biochem. 2015 Jun;116(6):1101-12.
10. Bioactive equivalence of combinatorial components identified in screening of an herbal medicine. Liu P, Yang H, Long F, Hao HP, Xu X, Liu Y, Shi XW, Zhang DD, Zheng HC, Wen QY, Li WW, Ji H, Jiang XJ, Zhang BL, Qi LW, Li P. Pharm Res. 2014 Jul;31(7):1788-800.
11. Regulation of mitochondrial morphology and function by stearoylation of TFR1. Senyilmaz D, Virtue S, Xu X, Tan CY, Griffin JL, Miller AK, Vidal-Puig A, Teleman AA. Nature. 2015 Sep 3;525(7567):124-8.
12. Biocompatible polymeric nanocomplexes as an intracellular stimuli-sensitive prodrug for type-2 diabetes combination therapy. Wang FZ, Xie ZS, Xing L, Zhang BF, Zhang JL, Cui PF, Qiao JB, Shi K, Cho CS, Cho MH, Xu X*(通讯作者), Li P*, Jiang HL*  Biomaterials. 2015 Dec;73:149-59.
13. Totarol prevents neuronal injury in vitro and ameliorates brain ischemic stroke: Potential roles of Akt activation and HO-1 induction. Gao Y, Xu X(共同一作), Chang S, Wang Y, Xu Y, Ran S, Huang Z, Li P, Li J, Zhang L, Saavedra JM, Liao H, Pang T. Toxicol Appl Pharmacol. 2015 Dec 1;289(2):142-54.
⑤联系方式
联系方式:025-83271382(o);
手机:18066069538
Email: xiaojunxu2000@163.com
通信地址:南京市童家巷24号科研大楼703室
邮编:210009