陈君

陈君,女,博士,博士研究生导师,特聘研究员。20007毕业于中国药科大学中药制药专业,获学士学位;20067月毕业于中国药科大学生药学专业,获博士学位,并留校任教。现为生药学系主任。入选教育部新世纪优秀人才支持计划

主要从事中药活性成分发现、作用机制与质量评价研究。主要基于中药“一药多效”特性,从与心血管疾病、器官纤维化等多种疾病发生、发展密切相关的氧化应激机制这一关键环节入手,集成多学科方法与手段,在信号分子、靶标蛋白、细胞信号传导通路等不同水平创建符合中药特点的活性成分群高效辨识新方法,从不同层次水平辨识活性成分,阐明其作用机制,回答中药众多成分中“哪些成分有效”,进而建立基于活性成分的质量评价方法。

主持国家自然科学基金项目4:基于比较代谢组学研究二妙丸类方抗高尿酸血症整体作用机制与药效物质基础(81773887);基于丹参酮小分子探针研究其抗血管内皮细胞氧化应激损伤的分子靶标及调控机制81573705);多靶垂钓/成分在线捕获方法的建立及在抗老年痴呆中药药效物质群研究中的应用(81073006);高效液相偶联自由基捕获检测系统用于中药抗氧化效应评价及其物质基础研究(30801521)。教育部新世纪优秀人才支持计划项目1项(中药质量评价,NCET-09-0769);负责完成了2010年版《中国药典》山银花、萹蓄等品种的质量标准起草;作为研究骨干,参与了国家自然科学基金重点项目、国家重大科技专项重大新药创制和国家863项目等课题的研究工作。为国家自然科学基金委创新群体、教育部创新团队的主要成员。共发表SCI收录论文47篇,全部论文被SCI他引742次,单篇他引最高81次,获授权发明专利10项。获2013年度教育部自然科学一等奖(排名第四),2009年度国家科学技术进步二等奖(排名第九)。指导本科生完成的作品获第十二届挑战杯全国大学生课外学术科技作品竞赛江苏省三等奖,指导本科生开展的国家大学生创新性实验计划项目入围第四届全国大学生创新年会学术论文大赛(2011年)。

代表性论文(*为通讯作者):

1)Yu-Yu Yang#, Xue-Yan Li#, Li-Ying Peng, Lin An, Ning-Yuan Sun, Xue-Wen Hu, Ping Zhou, Yong Xu, Ping Li*, Jun Chen*. Tanshindiol C inhibits oxidized low-density lipoprotein induced macrophage foam cell formation via a peroxiredoxin 1 dependent pathway, Biochimica et Biophysica Acta-Molecular Basis of Disease, 2018, 1864(3): 882~890.

2)Hong-Jin Tang#, Wei Li#, Mei Zhou, Li-Ying Peng, Jin-Xin Wang, Jia-Huang Li, Jun Chen*. Design, synthesis and biological evaluation of novel xanthine oxidase inhibitors bearing a 2-arylbenzo[b]furan scaffold. European Journal of Medicinal Chemistry, 2018, 151: 849~860.

3)Lin An, Mei Zhou, Faiz M. M. T. Marikar, Xue-Wen Hu, Qiu-Yun Miao, Ping Li, Jun Chen*. Salvia miltiorrhiza lipophilic fraction attenuates oxidative stress in diabetic nephropathy through activation of nuclear factor erythroid 2-related factor 2. American Journal of Chinese Medicine, 2017, 45(7): 1441~1457.

4)Xiao-Ling Bi, Kuo-Jun Zhang, Long He, Biao Gao, Qin-Lan Gu, Xue-Yan Li, Jun Chen*, Jin-Xin Wang*. Future Synthesis and biological evaluation of tanshinone IIA derivatives as novel endothelial protective agents. Future Medicinal Chemistry2017, 9(10):1073-1085.

5)Xue-Yan Li, Hong-Jin Tang, Liu Zhang, Lin Yang, Ping Li, Jun Chen*. A selective knockout method for discovery of minor active components from plant extracts: Feasibility and challenges as illustrated by an application to Salvia miltiorrhiza. Journal of Chromatography B20171068-1069:253-260.

6)Wei-Wei Tang, Bi-Xia Huang, Jian-Cheng Wang, Lin An, Huai-Ling Zhong, Hua Yang, Ping Li, Jun Chen*. A label-free screening approach targeted proteaseactivated receptor 1 based on dynamic mass redistribution in living cells. RSC Advances, 2017, 7:43005-43013.

7)Hong-Jin Tang, Xiao-Wei Zhang, Lin Yang, Wei Li, Jia-Huang Li, Jin-Xin Wang, Jun Chen*. Synthesis and evaluation of xanthine oxidase inhibitory and antioxidant activities of 2-arylbenzo[b]furan derivatives based on salvianolic acid C. European Journal of Medicinal Chemistry, 2016, 124: 637~648.

8)Hong-Jin Tang, Lin Yang, Jia-Huang Li*, Jun Chen*. Molecular modelling studies of 3,5-dipyridyl-1,2,4-triazole derivatives as xanthine oxidoreductase inhibitors using 3D-QSAR, Topomer CoMFA, molecular docking and molecular dynamic simulations. Journal of the Taiwan Institute of Chemical Engineers, 2016, 68:64-73.

9)Zhang Liu, Hui Zhang, Xue-Yan Li, Bing-Jie Jia, Yu-Yu Yang, Ping Zhou, Ping Li*, Jun Chen*. Miltirone protects human EA.hy926 endothelial cells from oxidized low-density lipoprotein-derived oxidative stress via a heme oxygenase-1 and MAPK/Nrf2 dependent pathway. Phytomedicine, 2016, 23:1806-1813.

   10)Hong-Jin Tang, Lin Yang, Wei Li, Jia-Huang Li, Jun Chen*. Exploring the interaction between Salvia miltiorrhiza and xanthine oxidase: insights from computational analysis and experimental studies combined with enzyme channel blocking. RSC Advances, 2016, 6:113527-113537.  

   11)Jin-Jin Lu, Bing-Jie Jia, Lin Yang, Wen Zhang, Xin Dong, Ping Li, Jun Chen*. Ultra-high performance liquid chromatography with ultraviolet and tandem mass spectrometry for simultaneous determination of metabolites in purine pathway of rat plasma. Journal of Chromatography B, 2016, 1036-1037:84-92.

   12)Jing Liu, Li-Ping Luo, Hui Zhang, Bing-Jie Jia, Jin-Jin Lu, Ping Li, Jun Chen*. Rapid screening for novel antioxidants in Glycyrrhiza inflata using high-resolution peak fractionation, Journal of Functional Foods, 2015.6, 16: 40~49.

13)Jun Lu, Hui-Peng Song, Ping Li*, Ping Zhou, Xin Dong, Jun Chen*, Screening of direct thrombin inhibitors from Radix Salviae Miltiorrhizae by a peak fractionation approach. Journal of Pharmaceutical and Biomedical Analysis, 2015, 109:85-90.

   14)Hui Zhang, Li-Ping Luo, Hui-Peng Song, Hai-Ping Hao, Ping Zhou, Lian-Wen Qi, Ping Li*, Jun Chen*. A high-resolution peak fractionation approach for streamlined screening of NF-E2-related factor-2 activators in Salvia miltiorrhiza. Journal of Chromatography A, 2014, 1326:47-55.

   15)Yu Fu, Hua-Yan Mo, Wen Gao, Jia-Ying Hong, Jun Lu, Ping Li*, Jun Chen*. Affinity selection-based two-dimensional chromatography coupled with high-performance liquid chromatography-mass spectrometry for discovering xanthine oxidase inhibitors from Radix Salviae Miltiorrhizae. Analytical and Bioanalytical Chemistry, 2014, 406:4987-4995.

16)Hui-Peng Song, Hui Zhang, Yu Fu, Hua-Yan Mo, Mu Zhang, Jun Chen*, Ping Li*. Screening for selective inhibitors of xanthine oxidase from Flos Chrysanthemum using ultrafiltration LC–MS combined with enzyme channel blocking. Journal of Chromatography B, 2014, 961:56-61.

17)Yu Fu, Jun Chen*, Yan-Jing Li, Yun-Feng Zheng, Ping Li*. Antioxidant and anti-inflammatory activities of six flavonoids separated from licorice. Food Chemistry, 2013, 141:1064-1071.

18)Wen Gao, Hua Yang, Lian-Wen Qi, E-Hu Liu, Mei-Ting Ren, Yu-Ting Yan, Jun Chen*, Ping Li*. Unbiased metabolite profiling by liquid chromatography- quadrupole time-of-flight mass spectrometry and multivariate data analysis for herbal authentication: classification of seven Lonicera species flower buds. Journal of Chromatography A, 2012, 1245:109-116.

19)Yan-Jing Li, Jun Chen*, Ying Li, Qin Li, Yun-Feng Zheng, Yu Fu, Ping Li*. Screening and charactrerization of natural antioxidants in four Glycyrrhiza species by liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry. Journal of Chromatography A, 2011, 1218:8181-8191.

20)Yan-Jing Li, Jun Chen*, Ying Li, Ping Li*. Identification and quantification of free radical scavengers in the flower buds of Lonicera species by online HPLC-DPPH assay coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry. BiomedicalChromatography, 2011, doi:10.1002/bmc.1685.

21)Yan-Jing Li, Huan-Li Wei, Lian-Wen Qi, Jun Chen*, Mei-Ting Ren, Ping Li*. Characterization and identification of saponins in Achyranthes bidentata by rapid-resolution liquid chromatography with electrospray ionization quadrupole time-of-flight tandem mass spectrometry. Rapid Communications in Mass Spectrometry, 2010, 24:2975-2985.

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