刘吉华

刘吉华,男,博士,教授,博士研究生导师,江苏省“六大人才高峰”第五批高层次人才培养对象,江苏省“333”工程第三层次培养对象。江苏省植物生理学会常务理事。

2、研究方向:

主要从事中药活性成分与生物技术研究工作。研究方向主要为中药药效物质基础、中药活性成分的生物转化及新药创制。

3、课题资助:

目前主持“十二五”国家重大新药创制专项、国家自然科学基金各一项,参加教育部优先发展领域项目一项。

近年来先后主持国家自然科学基金,教育部科学技术研究重点项目、江苏省“六大人才高峰”项目、国家区域科技支撑计划、江苏省研究生创新工程及企业研发课题等多项课题研究,作为主要研究人员参加科技部“十一五”重大新药创制、国家863重大专项、国家自然科学基金及等多项国家级和省部级科研项目研究工作。

4、联系方式:

电话:02586185157O),13057560609

电子邮件jihualiu88@163.com

5、近期主要代表文章

1.      Ye Xia, Ji-Hua Liu*, Jing-Han Liu, Bo-Yang Yu*Efficient Synthesis of Guanfu Base G via Highly Regioselective Lipase-catalyzed Acylation in Non-aqueous PhaseBioorganic & Medicinal Chemistry Letters, 2012,22(9):3100-3103

2.      Yuanyuan Zhang, Jihua Liu*, Junping Kou, Jun Yu, Boyang Yu*, DT-13 suppresses MDA-MB-435 cell adhesion and invasion by inhibiting MMP-2/9 via the p38 MAPK pathway, Mol Med Report, 2012, 6: 1121-1125

3.      L. Zhou,  W. Wang, S. H. Wei, Y. Y. Feng, J. H. Zhou, J. H. Liu* , J. Shen, Encapsulation of hydrophobic anticancer drug in nano-scale porous ceramic materials for photodynamic therapy, J Porous Mater, 2011, 18(4): 517-522

4.      Ji-Hua Liu, Bo-Yang YuBiotransformation of Bioactive Natural Products for Pharmaceutical Lead CompoundsCurrent Organic Chemistry, 2010, 14, 1400-1406

5.      Wang J1, Liu JH1, Guo X, Zhang J, Yu BY, A sensitive indirect competitive enzyme-linked immunosorbent assay for the detection of sarsasapogenin in rat plasma. Acta Pharmacol Sin ,2010, 31:984-989

6.      Ping Zhou 1, Shimon Gross1, Ji-Hua Liu 1, Bo-Yang Yu, Ling-Ling Feng,  Jan Nolta, Vijay Sharma, David Piwnica-Worms, Samuel X. Qiu , Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF- κB and MAPK signaling pathwaysThe FASEB Journal2010244722-4732

7.      Lin Zhou, Ji-Hua Liu, Fei Ma, Shao-Hua Wei, Yu-Ying Feng, Jia-Hong Zhou, Bo-Yang Yu, Jian Shen, Mitochondria-targeting photosensitizer-encapsulated amorphous nanocage as a bimodal reagent for drug delivery and biodiagnose in vitro, Biomed Microdevices, 2010, 12:655–663

8.      Nai-Dong Chen, Jian Zhang , Ji-Hua Liu and Bo-Yang YuMicrobial conversion of ruscogenin by Gliocladium deliquescens NRRL1086: glycosylation at C-1Applied Microbiology and Biotechnology2010862):491-497

9.      Nai-Dong Chen, Jian Zhang , Ji-Hua Liu and Bo-Yang YuHighly Efficient and Regio-selective Glucosylation of 25(S) Ruscogenin by Gliocladium deliquescens NRRL1086 Chinese Journal of Chemistry2010283):439-442

10.  Lin Zhou, Ji-Hua Liu, Jian Zhang, Shao-Hua Wei, Yu-Ying Feng, Jia-Hong Zhoua, Bo-Yang Yu, Jian ShenA new sol–gel silica nanovehicle preparation for photodynamic therapy in vitroInternational Journal of Pharmaceutics2010386131–137