莫然

    莫然,博士、教授、博士生导师。2012年获中国药科大学药剂学博士学位;2012年-2014年在美国北卡罗来纳大学教堂山分校/北卡州立大学联合生物医学工程系从事博士后研究;2014年底被聘为江苏特聘教授,作为海外高层次引进人才进入中国药科大学药物科学研究院工作。
    主要研究方向是药用功能材料及智能递药系统。从事科研工作以来,成功的结合药剂学、材料学、生物医学工程、化学等交叉学科的优势,设计开发了多种药用功能材料,并对其所构建的智能递药系统在疾病治疗中的应用进行了一系列深入的研究,取得了系统性的创新成果。已在Nature Nanotechnology、Nature Communications、J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、Adv. Mater.、Chem. Soc. Rev.等国际权威专业期刊上发表学术论文30余篇,其中IF>30的论文2篇,IF>10的论文11篇。研究成果被Nature、Nature Asia、Nature Reviews Drug Discovery、F1000 Prime等亮点报道。入选江苏特聘教授、中国药科大学海外高层次人才引进计划、中国科协“青年人才托举工程”、江苏省“六大人才高峰”计划、江苏省“双创”人才、江苏省“双创”团队。正主持国家自然科学基金面上项目、江苏省杰出青年基金等多项科研项目。曾获中国药学会以岭生物医药奖、中国药学会青年药剂学奖。

代表性论文:
1. Jingwei Xue, Zekai Zhao, Lei Zhang, Lingjing Xue, Shiyang Shen, Yajing Wen, Zhuoyuan Wei, Lu Wang, Lingyi Kong, Hongbin Sun, Qineng Ping, Ran Mo*, Can Zhang*. Neutrophil-mediated anticancer drug delivery for suppression of postoperative malignant glioma recurrence. Nat. Nanotechnol. 2017, 12, 692-700.

2.Ran Mo*, Zhen Gu*. Tumor microenvironment and intracellular signal-activated nanomaterials for anticancer drug delivery. Mater. Today2016, 19, 274-283.

3. Qiong Sun, Zisheng Kang, Lingjing Xue, Yunkai Shang, Zhigui Su, Hongbin Sun, Qineng Ping, Ran Mo*, Can Zhang*. A collaborative assembly strategy for tumor-targeted siRNA delivery. J. Am. Chem. Soc. 2015, 137, 6000-6010.

4. Tianyue Jiang, Wujin Sun, Qiuwen Zhu, Nancy A. Burns, Saad A. Khan, Ran Mo*, Zhen Gu*. Furin-mediated sequential delivery of anticancer cytokine and small-molecule drug shuttled by graphene. Adv. Mater. 2015, 27, 1021-1028. (Cover Feature)

5. Wujin Sun, Tianyue Jiang, Yue Lu, Margaret Reiff, Ran Mo*, Zhen Gu*. Cocoon-like self-degradable DNA nanoclew for anticancer drug delivery. J. Am. Chem. Soc. 2014, 136, 14722-14725.

6. Caoyun Ju, Ran Mo*, Jingwei Xue, Lei Zhang, Zekai Zhao, Lingjing Xue, Qineng Ping, Can Zhang*. Sequential intra-intercellular nanoparticle delivery system for deep tumor penetration. Angew. Chem. Int. Ed. 2014, 53, 6253-6258. (VIP Paper, Cover Feature)

7. Ran Mo*, Tianyue Jiang, Zhen Gu*. Enhanced anticancer efficacy by ATP-mediated liposomal drug delivery. Angew. Chem. Int. Ed. 2014, 53, 5815-5820.

8. Ran Mo, Tianyue Jiang, Rocco DiSanto, Wanyi Tai, Zhen Gu*. ATP-triggered anticancer drug delivery. Nat. Commun. 2014, 5, 3364. (Featured by Daily Headline of Nature)

9. Ran Mo, Tianyue Jiang, Jin Di, Wanyi Tai, Zhen Gu*. Emerging micro- and nanotechnology based synthetic approaches for insulin delivery. Chem. Soc. Rev.2014, 43, 3595-3629.

10. Ran Mo, Qiong Sun, Jingwei Xue, Nan Li, Wenyuan Li, Can Zhang*, Qineng Ping. Multistage pH-responsive liposomes for mitochondrial-targeted anticancer drug delivery. Adv. Mat.2012, 24, 3659-3665. (Cover Feature)


联系方式:
Email:rmo@cpu.edu.cn