莫然

    莫然198311月生。博士、教授、博士生导师。2012年获得中国药科大学药剂学专业博士学位;201210月至201410月在美国北卡罗来纳大学教堂山分校从事博士后研究工作;2014被评为江苏特聘教授、中国药科大学高层次人才引进特聘教授。

    从事科研工作以来,紧密结合药剂学、材料学、生物医学工程、化学等交叉专业背景的优势,围绕治疗及诊断用智能纳米药物递送系统的研究热点,取得了一系列标志性、创新性的研究成果。已在《Nature Communications》、《Angewandte Chemie International Edition》、《Journal of the American Chemical Society》、《Advanced Materials》、《Advanced Functional Materials》、《Chemical Society Reviews》等国际一流专业期刊上发表学术论文20篇。研究成果被《Nature》等杂志或媒体特别评论。并申请多项美国和中国专利,其中一项中国专利已授权。正主持江苏省自然科学基金杰出青年基金等多项科研项目。

 

主要研究方向:

1.    病灶微环境调控式纳米药物递送系统(Pathological Microenvironment-Modulated Nanosystem for Drug Delivery

2.    靶向能量代谢的疾病诊疗药物递送系统(Metabolism-Targeted Drug Delivery System for Disease Theranostics

3.    生理信号触发式药物智能释放系统(Physiological Signal-Activated Nanostructure for Controlled Drug Release

 

代表性论文:

1.    Qiong Sun, Zisheng Kang, Lingjing Xue, Yunkai Shang, Zhigui Su, Hongbin Sun, Qineng Ping, Ran Mo*, Can Zhang*, “A Collaborative Assembly Strategy for Tumor-Targeted siRNA Delivery”, J. Am. Chem. Soc. 2015, 137, 6000-6010. (IF: 12.113)

2.    Tianyue Jiang, Wujin Sun, Qiuwen Zhu, Nancy A. Burns, Saad A. Khan, Ran Mo*, Zhen Gu*, “Furin-mediated Sequential Delivery of Anticancer Cytokine and Small-Molecule Drug Shuttled by Graphene”, Adv. Mater. 2015, 27, 1021-1028. (Cover Feature, IF: 17.493)

3.    Wujin Sun, Tianyue Jiang, Yue Lu, Margaret Reiff, Ran Mo*, Zhen Gu*, “Cocoon-Like Self-Degradable DNA Nanoclew for Anticancer Drug Delivery”, J. Am. Chem. Soc. 2014, 136, 14722-14725. (IF: 12.113)

4.    Caoyun Ju, Ran Mo*, Jingwei Xue, Lei Zhang, Zekai Zhao, Lingjing Xue, Can Zhang*, “Sequential Intra-Intercellular Nanoparticle Delivery System for Deep Tumor Penetration”, Angew. Chem. Int. Ed. 2014, 53, 6253-6258. (Co-First Author, VIP Paper, Cover Feature, IF: 11.261)

5.    Ran Mo*, Tianyue Jiang, Zhen Gu*, “Enhanced Anticancer Efficacy by ATP-Mediated Liposomal Drug Delivery”, Angew. Chem. Int. Ed. 2014, 53, 5815-5820. (IF: 11.261)

6.    Ran Mo, Tianyue Jiang, Rocco DiSanto, Wanyi Tai, Zhen Gu*, “ATP-Triggered Anticancer Drug Delivery”, Nat. Commun. 2014, 5, 3364. (Featured by Nature (homepage headline news), IF: 11.470)

7.    Ran Mo, Tianyue Jiang, Jin Di, Wanyi Tai, Zhen Gu*, “Emerging Micro- and Nanotechnology based Synthetic Approaches for Insulin Delivery”, Chem. Soc. Rev. 2014, 43, 3595-3629. (IF: 33.383)

8.    Ran Mo, Qiong Sun, Jingwei Xue, Nan Li, Wenyuan Li, Can Zhang*, Qineng Ping, “Multistage pH-Responsive Liposomes for Mitochondrial-Targeted Anticancer Drug Delivery”, Adv. Mater. 2012, 24, 3659-3665. (Cover Feature, IF: 17.493)

 

联系方式:

Emailrmo@cpu.edu.cn; rmocpu@163.com