李娴静

  李娴静,副研究员,硕士生导师。2016年博士毕业于中国药科大学,同年留校从事教学与科研工作,致力于肿瘤免疫研究。以第一作者/共同第一作者或通讯作者在国际知名期刊PNASGutFASEB J等发表SCI论文7篇。主持国家自然科学基金面上项目一项、青年基金项目一项,江苏省自然科学基金青年基金一项,中央高校基本科研业务费重点及培育项目各一项。作为骨干成员参与十三五新药创制重大专项(2018ZX09201017-006、重大研究计划培育(91129731)及集成项目(91529304)。

联系方式:xjl@cpu.edu.cn

研究内容:

1.巨噬细胞活化对炎症性疾病的调节作用及分子机制

2.肿瘤相关巨噬细胞代谢特征、分子机制及干预策略

代表性论文:

1.Ye Zhang#, Xue Yang#, Wenchao Yan, Rui Li, Qian Ye, Linjun You, Wenhao Xie, Kun Mo, Ruifeng Fu, Yanxiang Wang, Yufei Chen, Hui Hou, Yong Yang, Lutz Birnbaumer*, Qin Di*, Xianjing Li*. Thymopentin improves the survival of septic mice by promoting the production of 15-deoxy-prostaglandin J2 and activating the PPARγ signaling pathway. FASEB J. 2020 Sep;34(9):11772-11785. (IF=4.99)

2.Duowei Wang#, Xianjing Li#, Jiani Li#, Yuan Lu#, Sen Zhao, Xinying Tang, Xin Chen, Jiaying Li, Yan Zheng, Shuran Li, Rui Sun, Ming Yan, Decai Yu, Guangwen Cao, Yong Yang*. APOBEC3B interaction with PRC2 modulates microenvironment to promote HCC progression. Gut. 2019 Oct; 68(10):1846-1857. (IF=19.8)

3.Xianjing Li#, Duowei Wang#, Zhen Chen#, Ermei Lu, Zhuo Wang, Jingjing Duan, Wei Tian, Yun Wang, Linjun You, Yulian Zou, Yan Cheng, Qingyi Zhu, Xiaojian Wan, Tao Xi, Meisheng Jiang, Yuyuan Han, Cong Cao, Lutz Birnbaumer*, Wen-Ming Chu*, Yong Yang*. Gαi1 and Gαi3 Regulate Macrophage Polarization by Forming a Complex Containing CD14 and Gab1. Proc Natl Acad Sci U S A. 2015 ;112(15):4731-6. (IF=9.5)

4.Xianjing Li#, Wang Zhuo#, Yulian Zou#, Ermei Lu, Jingjing Duan, Hongbao Yang, Qijin Wu, Xiaona Zhao, Yun Wang, Linjun You, Ling He, Tao Xi*, Yong Yang*. Pretreatment with lipopolysaccharide attenuates diethylnitrosamine-caused liver injury in mice via TLR4-dependent induction of Kupffer cell M2 polarization.Immunol Res. 2015;62(2):137-45. (IF=2.9)