周芳

   周芳,中国药科大学药物代谢动力学重点实验室,研究员,博士生导师。

教育部新世纪优秀人才,江苏省333工程第三层次人才,江苏省青年科技奖获得者。获江苏省科技进步一等奖等省部级以上奖励4项;主持国家自然科学基金4项、重大新药创制专项子课题2项、江苏省自然科学基金2项;以第一作者/通讯作者在Acta Pharmaceutica Sinica BBr J PharmacolActa Pharmacol SinDrug Metab DisposBiochem Pharmacol等药理/药代领域权威期刊发表SCI论文40余篇。

研究方向:

1. 细胞药代动力学及其与药效/毒性的关联研究

2. 靶向药物的成药性评价

3. 细胞治疗药物的药代-药效结合研究

联系方式:

E-mail: zf1113@163.com

Tel: 025-83271176

地址:玄武校区新科研大楼808,药物科学研究院,南京市童家巷24号,210009

 

代表性成果:

1.Zhong C, Jiang C, Ni S, Wang Q, Cheng L, Wang H, Zhang Q, Liu W, Zhang J, Liu J, Wang M, Jin M, Shen P, Yao X*, Wang G*, Zhou F*.  Identification of bioactive anti-angiogenic components targeting tumor endothelial cells in Shenmai injection using multidimensional pharmacokinetics.  Acta Pharm Sin B. 2020 ;10(9):1694-1708.  IF 11.413

2.Yao L, Zhang JW, Chen B, Cai MM, Feng D, Wang QZ, Wang XY, Sun JG, Zheng YW*, Wang GJ*, Zhou F*.  Mechanisms and pharmacokinetic/pharmacodynamic profiles underlying the low nephrotoxicity and ototoxicity of etimicin.  Acta Pharmacol Sin. 2020;41(6):866-878.  IF 6.15

3.Feng S, Wang H, Wang Y, Sun R, Xie Y, Zhou Z, Wang H, Aa J*, Zhou F*, Wang G.  Apatinib induces 3-hydroxybutyric acid production in the liver of mice by peroxisome proliferator-activated receptor α activation to aid its antitumor effect.  Cancer Sci. 2019;110(10):3328-3339.  IF4.966

4.Zang XJ, Wang GJ, Cai QY, Zheng X, Zhang JW, Chen QY, Wu BJ, Zhu X, Hao HP*, Zhou F*. A Promising Microtubule Inhibitor Deoxypodophyllotoxin Exhibits Better Efficacy to Multi-Drug Resistant Breast Cancer than Paclitaxel via Avoiding Efflux Transport. Drug Metab Dispos. 2018;46:542-551.    IF3.354

5.Liu J, Yan F, Chen H, Wang W, Liu W, Hao K, Wang G, Zhou F*, Zhang J*.   A novel individual-cell-based mathematical model based on multicellular tumour spheroids for evaluating doxorubicin-related delivery in avascular regions.   Br J Pharmacol. 2017;174(17):2862-2879.   IF5.491

6.Zhou F, Hao G, Zhang J, Zheng Y, Wu X, Hao K, Niu F, Luo D, Sun Y, Wu L, Ye W, Wang G*. Protectiveeffect of 23-hydroxybetulinic acid on doxorubicin-inducedcardiotoxicity: acorrelation with the inhibition of carbonyl reductase-mediated metabolism. Br J Pharmacol. 2015;172(23):5690-703.  IF5.491

2017年江苏省科技进步一等奖, 细胞药代动力学新理论技术体系的创建及其在新药研发和临床用药中的应用, 中国药科大学(王广基; 周芳;张经纬;郝海平; 阿基业; 孙建国; 郝琨; 梁艳; 彭英; 甄乐).