赖宜生

   赖宜生,博士,研究员,博士生导师,国家科学技术奖励、国家自然科学基金、教育部科研基金评审专家,入选江苏省“六大人才高峰”高层次人才。1991年硕士毕业于重庆大学,2004年博士毕业于中国药科大学。Journal of Medicinal Chemistry, European Journal of Medicinal Chemistry, Journal of Chemical Information and Modeling, Mini-Review in Medicinal Chemistry等杂志审稿人。
目前主要从事基于肿瘤发病机制中关键分子的创新药物研究,具体涉及靶向蛋白激酶、肿瘤代谢和肿瘤免疫的抗癌药物研究。近年来主持国家“重大新药创制”科技重大专项、国家自然科学基金、江苏省自然科学基金等10余项课题研究。先后在Angew Chem Int Ed、Chem Sci、J Med Chem、Euro J Med Chem、J Chem Inf Model、Mol Pharmaceut、Org Lett、J Org Chem等杂志发表70多篇SCI科研论文,被引用次数超过800次。参编出版《药物化学进展》、《中国药学年鉴》专著5部。已申请35项新药发明专利,其中15项已获得授权。
研究方向:新药分子设计与合成研究。
联系方式
通讯地址:南京市童家巷24号,科研大楼1710室,邮编210009。
E-mail:
yslai@cpu.edu.cn
代表性论文
1. Yi Zou, Fang Wang, Yan Wang, Qirui Sun, Yue Hu, Yuezhen Li, Wen Liu, Wenjie Guo, Zhangjian Huang, Yihua Zhang, Qiang Xu, Yisheng Lai. Discovery of imidazoleisoindole derivatives as potent IDO1 inhibitors: Design, synthesis, biological evaluation and computational studies. Euro. J. Med. Chem. 2017, 140: 293-304.
2. Yi Zou, Yan Wang, Fang Wang, Minghao Luo, Yuezhen Li, Wen Liu, Zhangjian Huang, Yihua Zhang, Wenjie Guo, Qiang Xu, Yisheng Lai. Discovery of potent IDO1 inhibitors derived from tryptophan using scaffold-hopping and structure-based design approaches. Euro. J. Med. Chem. 2017, 138: 199-211.
3. Yi Zou, Fang Wang, Yan Wang, Wenjie Guo, Yihua Zhang, Qiang Xu, Yisheng Lai. Systematic study of imidazoles inhibiting IDO1 via the integration of molecular mechanics and quantum mechanics calculations. Euro. J. Med. Chem. 2017, 131: 152-170.
4. Minghao Luo, Hui Wang, Yi Zou, Shengping Zhang, Jianhu Xiao, Guangde Jiang, Yihua Zhang, Yisheng Lai. Identification of phenoxyacetamide derivatives as novel DOT1L inhibitors via docking screening and molecular dynamics simulation. J. Mol. Graph. Model. 2016, 68: 128-139.
5. Yi Zou, Jianhu Xiao, Zhengchao Tu, Yingyi Zhang, Kun Yao, Ke Ding, Yihua Zhang, Yisheng Lai. Structure-based discovery of novel 4,5,6-trisubstituted pyrimidines as potent covalent Bruton’s tyrosine kinase inhibitors, Bioorg. Med. Chem. Lett. 2016, 26(13): 3052-3059.
6. Jianhu Xiao, Shengping Zhang, Minghao Luo, Yi Zou, Yihua Zhang, Yisheng Lai. Effective virtual screening strategy focusing on the identification of novel Bruton's tyrosine kinase inhibitors. J. Mol. Graph. Model. 2015, 60: 142-154.
7. Zhigao Shen, Xixian Pan, Yisheng Lai, Jiadong Hu, Xiaolong Wan, Xiaoge Li, Hui Zhang, Weiqing Xie. Chiral ion-pair organocatalyst promotes highly enantioselective 3-exo iodo-cycloetherification of allyl alcohols. Chem. Sci. 2015, 6(12): 6986-6990.
8. Shengping Zhang, Jiani Tan, Zhonghui Lai, Ying Li, Junxia Pang, Jianhu Xiao, Zhangjian Huang, Yihua Zhang, Hui Ji, Yisheng Lai. Effective virtual screening strategy toward covalent ligands: identification of novel NEDD8-activating enzyme inhibitors. J. Chem. Inf. Model. 2014, 54(6): 1785-1797.
9. Weiqing Xie, Guangde Jiang, Huan Liu, Jiadong Hu, Xixian Pan, Hui Zhang, Yisheng Lai, Dawei Ma. Highly enantioselective bromocyclization of tryptamine and its application on synthesis of (-)-chimonanthine. Angew. Chem. Int. Ed. 2013, 52(49): 12924-12927 (Hot paper)
10. Ran You, Wenyan Long, Zhonghui Lai, Lei Sha, Kai Wu, Xing Yu, Yisheng Lai, Hui Ji, Zhangjian Huang, Yihua Zhang. Discovery of a potential anti-inflammatory agent: 3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile. J. Med. Chem. 2013, 56(5): 1984-1995.