赖宜生

 赖宜生,博士,研究员,博士生导师,国家科学技术奖励、国家自然科学基金、教育部科研基金评审专家,入选江苏省六大人才高峰高层次人才。1991年毕业于重庆大学化学系,2004年获得中国药科大学药物化学专业博士学位。Journal of Medicinal Chemistry, European Journal of Medicinal Chemistry, Journal of Chemical Information and Modeling, Mini-Review in Medicinal Chemistry等杂志审稿人。

主要从事基于肿瘤发病机制中关键分子的创新药物研究,具体涉及靶向蛋白激酶、肿瘤代谢和肿瘤免疫的抗癌药物研究。近年来主持国家重大新药创制科技重大专项、国家自然科学基金、江苏省自然科学基金等10多项课题研究。先后在Angew Chem Int EdChem SciJ Med ChemEuro J Med ChemJ Chem Inf ModelMol PharmaceutOrg LettJ Org Chem等杂志发表70多篇SCI科研论文。参编出版《药物化学进展》、《中国药学年鉴》专著5部。申请48项发明专利,7PCT专利,其中20项已获得授权。

代表性论文

1. Yiqiang OuYang, Jian Gao , Lei Zhao, Junfeng Lu, Haiqing Zhong, Hua Tang, Shuanglong Jin, Lu Yue, Yuezhen Li, Wenjie Guo*, Qiang Xu*, Yisheng Lai*. Design, synthesis, and evaluation of o-(biphenyl-3-ylmethoxy)nitrophenyl derivatives as PD-1/PD-L1 inhibitors with potent anticancer efficacy in vivoJ Med Chem2021, 64(11): 7646-7666. (IF: 7.446)

2. Shushan Ge, Haiqing Zhong, Xuewei Ma, Yingbo Zheng, Yi Zou, Fang Wang, Yan Wang, Yue Hu, Yuezhen Li, Wen Liu, Wenjie Guo*, Qiang Xu*, Yisheng Lai*. Discovery of secondary sulfonamides as IDO1 inhibitors with potent antitumour effects in vivo. J Enzyme Inhib Med Chem202035(1): 1240-1257. (IF: 5.051)

3.Yi Zou,Yue Hu, Shushan Ge, Yingbo Zheng, Yuezhen Li, Wen Liu, Wenjie Guo*, Yihua Zhang, Qiang Xu*, Yisheng Lai*. Effective virtual screening strategy toward heme-containing proteins: Identification of novel IDO1 inhibitors. Eur J Med Chem2019184: 111750. (IF: 6.514)

4.Kun Yao, Pengyu Liu, Haipeng Liu, Qingyun Wei, Jie Yang, Peng Cao, Yisheng Lai*. 3D-QSAR, molecular docking and molecular dynamics simulations study of 3-pyrimidin-4-yl-oxazolidin-2-one derivatives to explore the structure requirements of mutant IDH1 inhibitors. J Mol Struct20191189: 187-202. (IF: 3.196)

5. Yi Zou, Fang Wang, Yan Wang, Qirui Sun, Yue Hu, Yuezhen Li, Wen Liu, Wenjie Guo*, Zhangjian Huang, Yihua Zhang, Qiang Xu*Yisheng Lai*. Discovery of imidazoleisoindole derivatives as potent IDO1 inhibitors: Design, synthesis, biological evaluation and computational studies. Euro J Med Chem,2017140: 293-304. (IF: 6.514)

6.Yi Zou, Yan Wang, Fang Wang, Minghao Luo, Yuezhen Li,Wen Liu, Zhangjian Huang, Yihua Zhang, Wenjie Guo*, Qiang Xu*Yisheng Lai*. Discovery of potent IDO1 inhibitors derived from tryptophan using scaffold-hopping and structure-based design approaches. Euro J Med Chem,2017138: 199-211. (IF: 6.514)

7.Yi Zou, Fang Wang, Yan Wang, Wenjie Guo, Yihua Zhang, Qiang Xu*Yisheng Lai*. Systematic study of imidazoles inhibiting IDO1 via the integration of molecular mechanics and quantum mechanics calculations. Euro J Med Chem,2017131: 152-170. (IF: 6.514)

8.Zhigao Shen,Xixian Pan, Yisheng Lai, Jiadong Hu, Xiaolong Wan, Xiaoge Li, Hui Zhang, Weiqing Xie. Chiral ion-pair organocatalyst promotes highly enantioselective 3-exo iodo-cycloetherification of allyl alcohols. Chem Sci20156(12): 6986-6990. (IF: 9.114)

9. Weiqing Xie*, Guangde Jiang, Huan Liu, Jiadong Hu, Xixian Pan, Hui Zhang, Yisheng Lai*, Dawei Ma*. Highly enantioselective bromocyclization of tryptamine and its application on synthesis of (-)-chimonanthine. Angew Chem Int Ed,201352(49): 12924-12927. (IF: 11.336, Hot Paper)

10. Ran You, Wenyan Long, Zhonghui Lai, Lei Sha, Kai Wu, Xing Yu, Yisheng Lai*, Hui Ji*, Zhangjian Huang, Yihua Zhang. Discovery of a potential anti-inflammatory agent: 3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrileJ Med Chem,201356(5): 1984-1995. (IF: 5.480)

招生专业:药物化学

研究方向:肿瘤免疫治疗研究

通讯地址:南京市童家巷24号,科研大楼1710室,邮编210009

E-mailyslai@cpu.edu.cn