陆涛

 

陆涛:男,1963年4月出生,教授,药物化学专业博士生导师,江苏省教学名师,现任中国药科大学副校长。1984年7月毕业于原南京药学院药物化学专业获学士学位,1989年6月毕业于中国药科大学药物化学专业获硕士学位,2001年5月毕业于中国药科大学药物化学专业获博士学位。2004年5月被聘为教授。2006年11月被聘为博士生导师。2000年10月任基础部副主任,2003年2月任基础部主任,2012年7月任理学院院长。2013年7月任中国药科大学副校长。
现担任国家基金委生命科学部通讯评议专家,国家发改委药品价格论证中心评审专家;教育部本科教学合格评估专家;江苏化学化工学会理事、有机化学专业委员会委员等学术职务。《中国药科大学学报》编委,多次受邀为European of Medicinal Chemistry、Journal of Molecular Modeling等多种SCI期刊担当审稿人。
课题组主要研究方向:(一)新药分子设计与合成研究:抗肿瘤信号转导通路KDR抑制剂、c-Met抑制剂、Raf激酶抑制剂、CDK抑制剂、Flt3 抑制剂、HDAC抑制剂等研究;(二)计算机辅助药物设计;(三)有机合成化学;(四)药物生物统计与计算药学。已完成国家及省部级课题多项,目前课题组在研项目主要有国家自然科学基金12项;教育部外国文教专家基金一项。自主研发的CDK/Flt3多靶点抑制剂作为临床前候选化合物以五千万合同价格转让给上海复星医药产业发展有限公司。已指导硕士研究生34名,指导博士研究生7名。课题组现有指导教师12名,博士生9名,硕士研究生46名。
 
近期发表主要论著:
1.        Du Ding*, Hu Zhongyuan, Jin Jianlin, Lu Yingyan, Tang Weifang, Wang Bo, Lu Tao*. N-Heterocyclic Carbene-Catalyzed Three-Component Domino Reaction of Alkynyl Aldehydes with Oxindoles. Organic Letters 2012, 14(5), 1274-1277
2.        Qingfa Zhou*, Xueping Chu, Weifang Tang, Tao Lu*, An efficient one-pot synthesis of 1,4-disubstituted 3-amino-2-pyridone derivatives via three-component reactions of alkynyl aldehydes and amines with ethyl 2-((diphenylmethylene)amino)acetate. Tetrahedron 68 (2012) 4152-4158
3.        Botao Xin, Weifang Tang, Yue Wang, Guowu Lin, Haichun Liu, Yu Jiao, Yong Zhu, Haoliang Yuan, Yadong Chen*, Tao Lu*, Design, synthesis and biological evalution of β-carboline derivatives as novel inhibitors targeting B-Raf kinase. Bioorganic & Medicinal Chemistry Letters 22 (2012) 4783–4786
4.        Wenhai Li*, Yue Wang, Tao Lu*, Facile synthesis of 1-aminoisoquinolines via the tandem reactions of 2-alkynylbenzaldoximes with isothiocyanates. Tetrahedron 68 (2012) 6843-6848
5.        Yingyan Lu, Weifang Tang, Yu Zhang, Ding Du* and Tao Lu*, N-Heterocyclic Carbene-Catalyzed Annulations of Enals and Ynals with Indolin-3-ones: Synthesis of 3,4-Dihydropyrano[3,2-b]indol-2-ones. Adv. Synth. Catal. 2013, 355, 321 – 326
6.        Chen Wang, De-Kai Ye, Yun-Yi Wang, Tao Lu* and Xing-Hua Xia*, Insights into the ‘‘free state’’ enzyme reaction kinetics in nanoconfinement. Lab on a Chip 2013, 13, 1546–1553
7.        Qing-Fa Zhou*, Xue-Ping Chu, Fei-Fei Ge, Cheng Li, Tao Lu*, Stereoselective syntheses of functionalized spirocyclopenteneoxindoles via triphenylphosphine-catalyzed [3+2] cycloaddition reactions. Mol. Divers. 2013, 17:563–571
8.        Qing-Fa Zhou*, Xue-Ping Chu, Fei-Fei Ge, Yue Wang, and Tao Lu*, Phosphine-Catalyzed [3+2] Annulation of Electron-Deficient Alkynes with N-Hydroxyphthalimide: Synthesis of 3a-Hydroxyisoxazolo[3,2-a]isoindol-8 (3aH)-ones. Adv. Synth. Catal. 2013, 355, 2787-2792
9.        Yuxi Tao, Junlin Liu, Zhihui Li, Jinguan Lin, Tao Lu*, Fangrong Yan*. Dose-Finding Based on Bivariate Efficacy-Toxicity Outcome Using Archimedean Copula. PLOS ONE 2013, 8(11) e78805,1-6
10.    Yanmin Zhang, Shangyan Yang, Yu Jiao, Haichun Liu, Haoliang Yuan, Shuai Lu, Ting Ran, Sihui Yao, Zhipeng Ke, Jinxing Xu, Xiao Xiong, Yadong Chen,* and Tao Lu*. An Integrated Virtual Screening Approach for VEGFR‑2 Inhibitors. J. Chem. Inf. Model. 2013, 53, 3163−3177 
11.    Sihui Yao, Tao Lu, Zifan Zhou, Haichun Liu, Haoliang Yuan, Ting Ran, Shuai Lu, Yanmin Zhang, Zhipeng Ke, Jinxing Xu, Xiao Xiong, Yadong Chen*. An efficient multistep ligand-based virtual screening approach for GPR40 agonists. Mol. Divers. 2014, 18, 183–193
12.    Qiao-Mei Jin, Yi Lu, Jian-Lin Jin, Hao Guo, Guo-Wu Lin, Yue Wang*, Tao Lu*. Synthesis, characterization, DNA binding ability and cytotoxicity of the novel platinum(II), copper(II), cobalt(II) and nickel(II) complexes with 3-(1H-benzo[d]imidazol-2-yl)-b-carboline. Inorganica Chimica Acta 2014, 421, 91–99
13.    Haoliang Yuan, Jin Zhuang, Shihe Hu, Huifang Li, Jinxing Xu, Yaning Hu, Xiao Xiong, Yadong Chen*, Tao Lu*.Molecular Modeling of Exquisitely Selective c‑Met Inhibitors through 3D-QSAR and Molecular Dynamics Simulations. J. Chem. Inf. Model. 2014, 54, 2544−2554
14.    Zhang, Yu; Lu, Yingyan; Tang, Weifang; Lu, Tao*; Du, Ding*. Cooperative N-heterocyclic carbene (NHC)-Lewis acid-mediated regioselective umpolung formal [3+2] annulations of alkynyl aldehydes with isatins. ORGANIC & BIOMOLECULAR CHEMISTRY  2014, 12(19), 3009-3015
15.    Weimin Yang, Yadong Chen, Xiang Zhou, Yazhou Gu, Wenqi Qian, Fan Zhang,
Wei Han, Tao Lu*, Weifang Tang*. Design, synthesis and biological evaluation of bis-aryl ureas and amides based on 2-amino-3-purinylpyridine scaffold as DFG-out B-Raf kinase inhibitors. European Journal of Medicinal Chemistry 2015, 89, 581−596
16.    Junyu Xu, Shihe Hu, Yingyan Lu, Ying Dong, Weifang Tang, Tao Lu,,*and Ding Du,* N-Heterocyclic Carbene-Catalyzed Umpolung Formal [3+3] Cycloaddition of Enals with Isatogens: Access to Fused Indolin-3-ones with a Tetrasubstituted Carbon Stereocenter. Adv. Synth. Catal. 2015, 357, 923 –927
17.    Xin Chen, Fei-Fei Ge, Tao Lu*, and Qing-Fa Zhou*, Stereoselective Synthesis of 3‑Methyleneisoindolin-1-ones via Base-2 Catalyzed Intermolecular Reactions of Electron-Deficient Alkynes 3 with N‑Hydroxyphthalimides. J. Org. Chem. 2015, 80, 3295−3301
18.    Hongmei Li, Zhen Li, Lixiang Liu, Tao Lu* and Yue Wang*, An efficient gold nanocarrier for combined chemophotodynamic therapy on tumour cells. RSC Adv., 2015, 5, 34831–34838
 
 
 
联系地址:江苏省南京市童家巷24号,中国药科大学(210009)
电    话:025-83271086,025-86185086  
传    真:025-83302827
E-mail: lutao@cpu.edu.cn