陆涛

陆涛:教授,药物化学专业博士生导师,江苏省教学名师,中国药科大学副校长。现担任全国药学专业学位研究生教育指导委员会副主任委员;中国药品监督研究会药品监管人才培养专业委员会主任委员;中国药学会科技评价工作委员会副主任委员;国家基金委生命科学部通讯评议专家,教育部本科教学审核评估专家;江苏省学位委员会委员;江苏化学化工学会理事、有机化学专业委员会委员等学术职务。《药学进展》执行主编,《中国药科大学学报》编委。主要研究方向:新药分子设计与合成研究、计算机辅助药物设计、有机合成化学、药物生物统计与计算药学。主持完成多项国家、省部级课题,目前在研国家自然科学基金2项,自主研发的抗肿瘤化合物以1.5亿合同价格转让给上海复星医药产业有限公司,目前正在美国、澳大利亚和中国同时开展I期临床研究,主要用于治疗急性髓细胞白血病(AML), 201911月该药物获美国FDA孤儿药资格认定。已发表SCI科研论文100余篇。指导博士研究生16名,硕士研究生90名。现有博士生6名,硕士研究生17名。

 

近期发表主要论著:

  1. Yanmin Zhang, Yadong Chen, Danfeng Zhang, Lu Wang, Tao Lu,* and Yu Jiao*. Discovery of Novel Potent VEGFR-2 Inhibitors Exerting Significant Antiproliferative Activity against Cancer Cell Lines. J. Med. Chem.2018, 61, 140-157 

  2. Yue Wang,Yanle Zhi,Qiaomei Jin,Shuai Lu,Guowu Lin, Haoliang Yuan,Taotao Yang,Zhanwei Wang,Chao Yao,Jun Ling,Hao Guo,Tonghui Li,Jianlin Jin,Baoquan Li,Li Zhang,Yadong Chen*,and Tao Lu*. Discovery of 4‑((7H‑Pyrrolo[2,3‑d]pyrimidin-4-yl)amino)‑N‑(4-((4-methylpiperazin-1-yl)methyl)phenyl)‑1H‑pyrazole-3-carboxamide (FN-1501), an FLT3- and CDK-Kinase Inhibitor with Potentially High Efficiency against Acute Myelocytic Leukemia. J. Med. Chem. 2018, 61, 1499-1518

  3. Li Zhang, Jingyun Zhao, Beichen Zhang, Tao Lu*, Yadong Chen*. Discovery of [1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives as novel, potent and selective c-Met kinase inhibitors: Synthesis, SAR study, and biological activity. Eur. J. Med. Chem. 2018, 150, 809816

  4.  Lu Wang, Yanmin Zhang, Qing Zhang, Gaoyuan Zhu, Zhimin Zhang, Chunqi Duan, Tao Lu*, Weifang Tang*. Discovery of potent Pan-Raf inhibitors with increased solubility to overcome drug resistance. Eur. J. Med. Chem. 2019, 163, 243255.

  5.  Qi Y. Wang, Hong M. Li, Zhi P. Dong, Bing X. Li, Ming Huo, Tao Lu* and Yue Wang*. Peptide-mediated cationic micelles drug-delivery system applied on a VEGFR3-overexpressed tumor. J. Mater. Chem. B, 2019, 7, 10761086.

  6. Shuaishuai Fang, Shiyi Jin, Rui Ma, Tao Lu*, Ding Du*. Asymmetric Synthesis of C2-Quaternary Indolin-3-ones Enabled by N-Heterocyclic Carbene Catalysis. Org. Lett. 2019, 21, 5211-5214.  

  7. Yin LongXing JunhaoWang YuhanShenYueLu Tao*Hayashi Tamio*Dou Xiaowei*. Enantioselective Synthesis of 3,3'-Diaryl-SPINOLs: Rhodium-Catalyzed Asymmetric Arylation/BF3 -Promoted Spirocyclization Sequence.  Angew Chem Int Ed Engl. 2019, 58(8), 2474-2478.

  8. Fei Jiang,Qinghua Hu,Zhimin Zhang,Hongmei Li,Huili Li,Dewei Zhang,Hanwen Li, Yu Ma,Jingjing Xu,Haifang Chen,Yong Cui,Yanle Zhi, Yanmin Zhang,Junyu Xu, Jiapeng Zhu*,Tao Lu*,and Yadong Chen*. Discovery of Benzo[cd]indol-2(1H)ones and Pyrrolo[4,3,2-de]quinolin-2(1H)ones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain with Potential High Efficiency against Acute Gouty Arthritis. J. Med. Chem.2019, 62, 1108011107

  9. Wang Qi YLi, Hong M Dong, ZPLi, Bing XHuo, MingLu, Tao*Wang Yue*. Peptide-mediated cationic micelles drug-delivery system applied on a VEGFR3-overexpressed tumor. J Mater Chem B. 2019, 7(7), 1076-1086.   

  10. Hong-Mei Li, Yan-Ran Bi, Yang Li, Rong Fu, Wen-Cong Lv, Nan Jiang, Ying Xu,Bo-Xue Ren, Ya-Dong Chen, Hui Xie, Shui Wang, Tao Lu*, Zhao-Qiu Wu*. A potent CBP/p300-Snail interaction inhibitorsuppresses tumor growth and metastasis inwild-type p53-expressing cancer. Sci. Adv. 2020; 6 : eaaw8500

     

     

     

    联系地址:江苏省南京市童家巷24号,中国药科大学(210009

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    E-mail: lutao@cpu.edu.cn