陈莉

陈莉,女,教授,博导。1988年本科毕业于中国药科大学化学制药专业;2004年博士毕业于中国药科大学药物化学专业。中国药学会会员,九三学社社员,江苏省教育厅青蓝工程中青年学术带头人,20124-20134月于美国伊利诺伊大学芝加哥校区(University of Illinois Chicago)从事访问学者研究。国家自然科学基金化学部同行评审专家,Journal of Medicinal Chemistry, European Journal of Medicinal Chemistry , Bioorganic & Medicinal Chemistry Letters 等杂志审稿人。

研究方向
01天然产物结构修饰、改造和生物活性研究
 02
天然药物与中药的活性成分研究)

主持科研项目情况

主持及参与国家自然科学基金面上项目、江苏省自然科学基金面上项目、陕西省肿瘤精准医学重点实验室开放课题等数项国家及省部级科研项目。近年还与多家企业合作开展来源于天然产物的抗肿瘤药物研发等横向研究项目,主持和参与(主要成员)各一项“双一流”学科高原项目。

5年发表的通讯作者论文

  1. Shi ZX, Li N, Chen C, Wang YJ, Lei ZC, Chen L*, Sun JB*. Novel NO-releasing scopoletin derivatives induce cell death via mitochondrial apoptosis pathway and cell cycle arrest. Eur J Med Chem, 2020, 200:1-14.

  2. Li N, Ou JF, Bao N, Chen C, Shi ZX, Chen L*, Sun JB*. Design, synthesis and biological evaluation of novel plumbagin derivatives as potent antitumor agents with STAT3 inhibition. Bioorg Chem, 2020, 104:1-10.

  3. Li N#, Xu MY#, Wang B, Shi ZX, Zhao ZH, Tang YQ, Wang XY,Sun JB*, Chen L*. Discovery of novel celastrol derivatives as Hsp90-Cdc37 interaction disruptors with antitumor activity. J Med Chem, 2019, 62: 10798-10815.

  4. Xu MY, Li N, Zhao ZH, Shi ZX, Sun JB*, Chen L*. Design, synthesis and antitumor evaluation of novel celastrol derivatives. Eur J Med Chem, 2019, 174:265-276.

  5. Hu YP, Li N, Zhang JY, Wang Y, Chen L*, Sun JB*. Artemisinin-indole and artemisinin-imidazole hybrids: Synthesis, cytotoxic evaluation and reversal effects on multidrug resistance in MCF-7/ADR cells. Bioorg Med Chem Lett, 2019, 29: 1138-1142.

  6. Liu GQ, Yang JB, Su BL, Liao RZ, Zhou W*, Chen L*. Design and synthesis of novel 3, 4-diaminobenzoyl derivatives as antithrombotic agents with improved solubility. Chem Pap, 2019, 73: 987-994.

  7. Li N, Xu MY, Bao N, Shi W, Li QX, Zhang XW, Sun JB*, Chen L*. Discovery of novel NO-releasing celastrol derivatives with Hsp90 inhibition and cytotoxic activities. Eur J Med Chem, 2018, 160: 1-8.

  8. Bao N#, Ou JF#, Li N, Zou P, Sun JB*,Chen L*. Novel anticancer hybrids from diazen-1-ium-1, 2-diolate nitric oxide donor and ROS inducer plumbagin: Design, synthesis and biological evaluations.Eur J Med Chem, 2018, 154:1-8.

  9. Li QX, Zou P,Sun JB*,Chen L*. O2-(2, 4-dinitrophenyl) diazeniumdiolates derivatives: Design, synthesis, cytotoxic evaluation and reversing MDR in HepG-2/ADR cells.Eur J Med Chem, 2018, 143:732-744.

  10. Bao N#, Ou JF#, Shi W, Li N,Chen L*, Sun JB*. Highly Efficient Synthesis and Structure-Activity Relationships of a Small library of Substituted 1, 4-Naphthoquinones.Eur J Org Chem, 2018, (19): 2254-2258.

  11. WangB, Li Q, Shi W, Chen L*, Sun JB*. Design, synthesis, and cytotoxic evaluation of novel furo [2, 3-b]quinoline derivatives. Chem Biol Drug Des,2018, 91: 957-961.

  12. Zhang JY, Chen L*, Sun JB*. Oxoisoaporphine Alkaloids: Prospective Anti-Alzheimer’s Disease, Anticancer, and Antidepressant Agents.Chem Med Chem,2018, 13, 1262-1274.

  13. Bao N#, Ou JF#, Xu MY, Guan FQ, Shi W, Sun JB*,Chen L*. Novel NO-releasing plumbagin derivatives: Design, synthesis and evaluation of antiproliferative activity.Eur J Med Chem, 2017, 137: 88-95.

  14. Shi W#, Zhang JL#, Bao N, Guan FQ,Chen L*, Sun JB*. Design, synthesis and cytotoxic evaluation of novel scopoletin derivatives.Chem Biol Drug Des,2017, 91: 641-646.

  15. Liu ZK, Fang L*, Zhang H, Gou SH,Chen L*. Design, synthesis and biological evaluation of multifunctional tacrine-curcumin hybrids as new cholinesterase inhibitors with metal ions-chelating and neuroprotective property.Bioorg Med Chem, 2017, 25: 2387-2398.

  16. Shi W, Hu JL, Bao N, Li DG, Chen L*, Sun JB*. Design, synthesis and cytotoxic activities of scopoletin-isoxazole and scopoletin-pyrazole hybrids.Bioorg Med Chem Lett,2017, 27:147-151.

  17. Liu Y#, Wang TT#, Ling Y, Bao N, Shi W,Chen L*, Sun JB*. Design, synthesis and cytotoxic evaluation of nitric oxide-releasing derivatives of isosteviol.Chem Biol Drug Des,2017, 90: 473-477.

  18. Liu JH, Zhu ZF, Tang J, Lin QH,Chen L*, Sun JB*. Design and Synthesis of NO-releasing Betulinic Acid Derivatives as Potential Anticancer Agents.Anti-cancer agent me, 2017, 17: 241-249.

  19. Sun JB*, Jiang N, Lv MY, Tang BQ, Wang P, Liang JY,Chen L*.Anstifolines A and B, two dimeric furoquinoline alkaloids from the root bark of Dictamnus angustifolius.RSC Advances, 2016, 47: 22550-22554.

  20. Fang L, Chen MH, Liu ZK, Fang XB, Gou SH*,Chen L*. Ferulic acid–carbazole hybrid compounds: Combination of cholinesterase inhibition, antioxidant and neuroprotection as multifunctional anti-Alzheimer agents.Bioorg Med Chem, 2016, 24: 886-893.

  21. Sun JB#, Tang BQ#, Li QQ, Wang B, Liang JY*,Chen L*. Cytotoxic limonoids from the root bark of Dictamnus angustifolius.Fitoterapia,2016, 115: 92-95.

  22. Sun JB, Wang P, Liang JY*,Chen L*. Phytochemical and chemotaxonomic study on Dictamnus angustifolius G. Don ex Sweet (Rutaceae).Biochemical Systematics and Ecology,2016, 68:74-76.

  23. Li LH, Zhao P, Hu JL, Liu JH, Liu Y, Wang ZQ, Xia YF*, Dai Y,Chen L*. Synthesis, in vitro and in vivo antitumor activity of scopoletin-cinnamic acid hybrids.Eur J Med Chem,2015, 93: 300-307.

  24. Ling YWang ZQWang XMLi XHWang XYZhang WDai H*Chen L*Zhang YH. Hybrid molecule from FTS-diamine and phenylpropenoic acid as Ras-related signaling inhibitor with potent antitumor activities.Chem Biol Drug Des, 2015, 85: 145-152.

  25. Liu JH, Zhu ZF, Tang J, Jiang AQ*, Hu LF,Chen L*. Novel NO-releasing derivatives of betulinic acid with antitumor activity. Chin Chem Lett, 2015, 26: 759-762.

  

联系方式
Tel13814083082E-mailchenli627@cpu.edu.cn
通讯地址:南京市童家巷24号,中国药科大学天然药物化学系