罗建光

罗建光,男,博士,教授,博士生导师
1998年6月本科毕业于湖南中医药大学药学院;1998年7月~2001年7月进入湖南宏生堂制药有限公司技术开发部工作;2001年9月~2006年6月就读中国药科大学中药学专业研究生,获博士学位;2006年7月~2007年6月中国海洋大学医药学院任讲师;2007年7月至今,中国药科大学天然药物化学教研室教师。2013年5月~2014年5月美国亚利桑那大学(University of Arizona)访问学者。入选教育部“新世纪优秀人才计划”,江苏省“333工程”第二层次培养对象。
主要研究方向
1. 中药及天然药物中新奇活性成分发现及相关技术研究
  2.活性天然分子靶标发现导向的化学生物学研究
   
主持项目与研究成果:
主持了国家自然科学基金面上项目、“十二五”国家新药创新重大专项、教育部博士点基金等10余项课题。参加编写了《波谱解析》(人民卫生出版社第1、2版,科学出版社案例版)和《复杂天然产物波谱解析》等5部教材和著作,近5年以第一或通讯作者发表研究性SCI论文48篇,获授权专利6项。
  研究成果“中药及天然药物活性成分分离新技术研究与应用”获国家科技进步二等奖(2015年,排名第4);“中药化学成分分离新方法体系的建立及相关中药质量控制研究”获教育部科技进步奖二等奖(2012年,排名第2),“若干重要药用植物的生物活性成分研究”获得江苏省科学技术奖一等奖(2013年,排名第2)。
   
代表性论文:
1.Zhang YL, Chen C, Wang XB, Wu L, Yang MH, Luo J, Zhang C, Sun HB, Luo JG*, Kong LY*. Rhodomyrtials A and B, Two Meroterpenoids with a Triketone-Sesquiterpene-Triketone Skeleton from Rhodomyrtus tomentosa: Structural Elucidation and Biomimetic Synthesis. Org Lett, 2016, 18, 4068-71. SCI IF: 6.732
  2.Li QM #, Luo JG#, Zhang YM, Li ZR, Wang XB, Yang MH, Luo J, Sun HB, Chen YJ, and Kong LY*. Involucratustones A-C: Unprecedented sesquiterpene dimers containing multiple contiguous quaternary carbons from Stahlianthus involucratus. Chem Eur J, 2015, 21(38), 13206-9. SCI IF: 5.731
  3.2. Xu JF, Zhao HJ, Wang XB, Li ZR, Luo J, Yang MH, Yang L, Yu WY, Yao HQ, Luo JG,* and Kong LY*. (±)-Melicolones A and B, rearranged prenylated acetophenone stereoisomers with an unusual 9‑oxatricyclo [3.2.1.13,8] nonane core from the leaves of Melicope ptelefolia. Org Lett, 2015, 17, 146-9. SCI IF: 6.346
  4.Luo JG, Wang XB, Xu YM, U’Ren JM, Arnold AE, Kong LY, and Gunatilaka AAL*, Delitschiapyrone A, a Pyrone−naphthalenone adduct bearing a new pentacyclic ring system from the leaf-associated fungus Delitschia sp. FL1581, Org Lett, 2014, 16, 5944-7. SCI IF: 6.346
  5.Yin H, Luo JG*, Shan SM, Wang XB, Luo J, Yang MH, and Kong, LY. Amomaxins A and B, two unprecedented rearranged labdane norditerpenoids with a nine- membered ring from Amomum maximum. Org Lett, 2013, 15, 1572-5. SCI IF: 6.732
  6. Li QM#, Luo JG#, Wang RZ, Wang XB, Yang MH, Luo J,Kong LY*. Involucratusins A–H: Unusual Cadinane Dimers from Stahlianthus involucratus with Multidrug Resistance Reversal Activity. Scientific Reports, 2016, 6, 29744-55. SCI IF: 5.228
  7. Ma T, Fan BY, Zhang C, Zhao HJ, Han C, Gao CY, Luo JG* and Kong LY*. Metabonomics applied in exploring the antitumour mechanism of physapubenolide on hepatocellular carcinoma cells by targeting glycolysis through the Akt-p53 pathway. Scientific Reports, 2016, 6, 29926-42. SCI IF: 5.228
  8. Wang SS, Han C, Wang SS, Bai LJ, Li SS, Luo JG*, Kong LY*, Development of a high speed counter-current chromatography system with Cu(II)-chiral ionic liquid complexes and hydroxypropyl-β-cyclodextrin as dual chiral selectors for enantioseparation of naringenin. J Chromat A, 2016, 1471, 155–63. SCI IF: 3.926
  9. Xue GM, Xia YZ, Wang ZM, Li LN, Luo JG*, Kong LY*. neo-Clerodane diterpenoids from Scutellaria barbata mediated inhibition of P-glycoprotein in MCF-7/ADR cells. Eur J Med Chem, 2016,121, 238-49. SCI IF: 3.902
  10. Yang BY , Kong LY*, Wang XB, Zhang YM, Li RJ, Yang MH, Luo JG*. Nitric Oxide Inhibitory Activity and Absolute Configurations of Arylalkenyl α,β-Unsaturated δ/γ-Lactones from Cryptocarya concinna. J Nat Prod, 2016, 79, 196−203. SCI IF: 3.662
  11. Ma T, Zhang N, Yang L, Zhang C, Lin L, Shan SM, Zhu MD, Luo JG* and Kong LY*. Cytotoxic withanolides from Physalis angulata var. villosa and the apoptosis-inducing effect via ROS generation and the activation of MAPK in human osteosarcoma cells. RSC Advances, 2016, 6, 53089-53100. SCI IF: 3.289
  12. Zhao HJ, Ma T, Fan BY, Yang L, Han C,Luo JG*, Kong LY*. Protective effect of trans-δ-viniferin against high glucose-induced oxidative stress in human umbilical vein endothelial cells through the SIRT1 pathway. Free radical research. 2016, 50, 68-83. SCI IF: 2.976
  13. Fan BY, Gu YC, He Y, Li ZL, Luo JG*, and Kong, LY*. Cytotoxic resin glycosides from Ipomoea aquatica and their effects on intracellular Ca 2+ concentrations. J Nat Prod, 2014, 77, 2264-72. SCI IF: 3.947
  14. Han C, Xu JF, Wang XB, Xu XM, Luo JG*, and Kong LY*. Enantioseparation of racemic trans-δ-viniferin using high speed counter-current chromatography based on induced circular dichroism technology. J Chromatogr A, 2014, 1324, 164–70. SCI IF: 4.258
  15. Liu, QW, Liao XL, Xu J, Zhao J, Luo JG∗, Kong LY∗. Development and validation of a sensitive and selective LC–MS/MS method for the determination of trans δ-veniferin, a resveratrol dehydrodimer, in rat plasma and its application to pharmacokinetics and bioavailability studies. J. Chromatogr. B, 2014, 958, 124-9. SCI IF: 2.694
   
联系方式:
Tel:025-83271402 (o);E-mail:luojg@cpu.edu.cn
  通信地址:南京市童家巷24号,中国药科大学天然药物化学教研室,邮编210009