张浩



张浩,博士,教授,博士研究生导师。2008年本科毕业于中国药科大学,2012年博士毕业于中国医学科学院北京协和医学院。20136月至20167月在美国普渡大学癌症中心从事博士后研究。目前担任药学学报中英文双刊青年编委,中国抗癌协会抗癌药物专业委员委员,中国医疗保健国际交流促进会中药学分会委员。主持国家自然科学基金(3项)、重大新药创制子课题、江苏省自然科学基金面上项目、江苏省科协青年科技人才托举工程等项目。以第一/通讯作者在Journal of HepatologyHepatology, STTTBJP,APSBCancer Research等国内外著名杂志发表论文20余篇。


研究方向:肝脏疾病及肿瘤的新靶点确证和天然活性物质研究。


代表性论文:

1.Jie Li#, Xiaoyun Zhu#, Meihui Zhang, Yanqiu Zhang, Shengtao Ye, Yingrong Leng, Ting Yang, Lingyi Kong*, Hao Zhang*.Limb expression 1-like (LIX1L) protein promotes cholestatic liver injury by regulating bile acid metabolism. Journal of Hepatology, 2021

2. Hao Zhang#, Yanqiu Zhang#, Xiaoyun, Zhu Chen Chen, Chao Zhang,Yuanzheng Xia, Yucheng Zhao, Ourania Andrisani, Lingyi Kong*, DEAD Box Protein 5 Inhibits Liver Tumorigenesis by Stimulating Autophagy via Interaction with p62/SQSTM1,Hepatology, 2019

3. Xiaoyun Zhu, Yanqiu Zhang, Yucheng Zhao, Dejuan Xiang, Jie Zou, Ourania Andrisani, Hao Zhang*, Lingyi Kong*. LIX1-like protein drives hepatic stellate cell activation to promote liver fibrosis by regulation of chemokine mRNA stability. Signal Transduction and Targeted Therapy, 2021

4.Xiaoyun Zhu, Shengtao Ye, Dongke Yu, Yanqiu Zhang, Jie Li , Meihui Zhang, Yingrong Leng, Ting Yang, Jianguang Luo , Xinlin Chen, Hao Zhang*, Lingyi Kong*. Physalin B attenuates liver fibrosis via suppressing LAP2α‐HDAC1 mediated deacetylation of GLI1 and hepatic stellate cell activation. British Journal of Pharmacology, 2021

5.Jie Zou#, Xiaoyun Zhu#, Dejuan Xiang, Yanqiu Zhang, Jie Li, Zhigui Su, Lingyi Kong*, Hao Zhang*, LIX1-like protein promotes liver cancer progression via miR-21-3p-mediated inhibition of fructose-1,6- bisphosphatase, Acta Pharmaceutica Sinica B, 2021

6. Hao Zhang, Zheng Xing, Saravana Kumar Kailasam Mani, Brigitte Bancel, David Durantel, Fabien Zoulim, Elizabeth J. Tran, Philippe Merle, Ourania Andrisani*RNA Helicase DEAD Box Protein 5 Regulates Polycomb Repressive Complex 2/Hox Transcript Antisense Intergenic RNA Function in Hepatitis B Virus Infection and Hepatocarcinogenesis, Hepatology2016

 

联系方式:

通讯地址:南京市童家巷24号,科研大楼1609

邮政编码:210009

电子信箱:zhanghao@cpu.edu.cn