药学名家讲座第138期公告

江苏省现代药物领域研究生创新与学术交流中心

2018年中国药科大学研究生培养创新学术活动

药学名家讲座第一百三十八期

讲座题目:Recent advance in developing photolabile protecting

groups and soponin-based vaccine adjuvants

讲座时间:20180612日(周二)下午1500-1630

讲座地点:中国药科大学玄武门校区学术交流中心206报告厅

主讲人Prof. Pengfei Wang阿拉巴马大学伯明翰分校

主持人黄张建特聘研究员中国药科大学新药研究中心

主办单位:江苏省代谢性疾病药物重点实验室

中国药科大学新药研究中心

中国药科大学研究生院、药物科学研究院

中国药科大学药青会

江苏省现代药物领域研究生创新与学术交流中心

聆听名师讲座启迪学术智慧拓宽创新视野

欢迎各位老师和同学们踊跃参加!

报告人简介:

Pengfei Wang

Professor, Member of American Chemical Society.
Chemistry Building 278
(205) 996-5625

Research and Teaching Interests: Organic Chemistry, Photochemistry, Carbohydrate Chemistry, Synthetic Methodology, Photoresponsive Materials, Synthetic Vaccines and Vaccine Adjuvants

Education:

·BS, Tsinghua University, Chemistry

·MS, University of Illinois at Chicago, Physical Chemistry

·PhD, University of Wisconsin-Madison, Organic Chemistry

·Postdoctoral, University of Wisconsin-Madison, Physical Organic Chemistry

·Postdoctoral, University of Illinois at Urbana-Champaign, Carbohydrate Synthesis

Dr. Wang is originally from China, and received his undergraduate education at Tsinghua University in Beijing, China (BS and B.Eng.) and graduate education at the University of Illinois at Chicago (MS) and the University of Wisconsin-Madison (PhD). At UW-Madison, Dr. Wang focused on studying kinetic protonation of enols, a classical physical organic chemistry topic, under the supervision of Professor Howard E. Zimmerman. He then joined Professor David Y. Gin at the University of Illinois-Urbana as a postdoctoral associate, working on natural product synthesis.

In 2005, Dr. Wang started his independent academic career at UAB, focusing on discovery of novel organic reactions and development of new methodologies for application in organic synthesis, biochemical and biophysical research, medicinal chemistry, and materials science

Research Interests:

Our ongoing research projects include (1) development of photolabile protecting groups (PPGs), (2) application of PPGs in synthesis, light-responsive smart materials, controlled release of biologically important compounds, and light-activated anticancer prodrugs, (3) application of new photochemical bond formation reactions in crosslinking macromolecules, labelling proteins, and tissue engineering, (4) development of new facile glycosylation methods, (5) synthesis of carbohydrate antigens for the development of carbohydrate-based vaccines, and (6) development of clinically relevant saponin-based vaccine adjuvants.

Recent Publications:

·Ding, X.; Wang, P. Photochemical cleavage of benzylic C−O bond facilitated by an ortho or meta amino group. J. Org. Chem. 2017, 82, 7309-7316.

·Wang, P. Developing photolabile protecting groups based on the excited state meta effect. J. Photochem. Photobiol A: Chem. 2017, 335, 300-310 (invited feature article, cover).

·Wang, P.; Devalankar, D.; Dai, Q.; Zhang, P.; Michalek, S. Synthesis and Evaluation of QS-21-Based Immunoadjuvants with a Terminal-Functionalized Side Chain Incorporated in the West Wing Trisaccharide. J. Org. Chem. 2016, 81, 9560-9566.

·Ding, X.; Devalankar, D.; Wang, P. Structurally Simple Benzylidene-Type Photolabile Diol Protecting Groups. Org. Lett. 2016, 18, 5396-5399.

·Wang, P.; Devalankar, D.; Lu, W. Photochemical cleavage of benzylic C-N bond to release amines. J. Org. Chem. 2016, 81, 6195-6200.

·Wang, P.; Lu, W.; Devalankar, D.; Ding, Z. Structurally simple benzyl-type photolabile protecting groups for direct release of alcohols and carboxylic acids. Org. Lett. 2015, 17, 2114-2117.

·Wang, P.; Lu, W.; Devalankar, D.; Ding, Z. Photochemical formation and cleavage of C−N bond. Org. Lett.2015, 17, 170-172.

·Wang, P.; Dai, Q.; Thogaripally, P.; Zhang, P.; Michalek, S. M. Synthesis of QS-21-Based Immunoadjuvants. J. Org. Chem. 2013, 78, 11525-11534.

·Lu, W.; Tian, C.; Thogaripally, P.; Hu, J.; Wang, P. Application of new photolabile protecting groups as photocleavable joints of block copolymers. Chem. Commun. 2013, 49, 9636-9638.