孙丽萍

  孙丽萍,女,博士,药物化学教授,博士生导师。江苏省高校“青蓝工程” 中青年学术带头人。
学习与工作经历
1988年毕业于西北师范大学,1991年获中科院兰州化学物理研究所硕士学位,2004年获香港科技大学博士学位, 2005年1月至2006年1月在新加坡国立大学从事博士后研究,2006年底至今在中国药科大学任教。
研究方向:新药分子设计与合成研究。 研究领域包括基于炎症和抗肿瘤药物的设计与评价研究、活性天然产物的结构改造和成药性优化研究以及金属催化的小分子药物的合成方法学研究。
承担科研项目:
1. 主持国家自然科学基金项目(20742003,20872181,21172265,21472243)
2. 参加国家自然科学基金重大研究计划项目(90713038)
3. 参加“重大新药创制”科技重大专项 “十一五”计划项目(2009ZX09501-003)
承担课程:有机合成反应,药物合成反应,化学生物学选论,新药设计与合成
代表性论文:
1.Hai-Qi Zhang, Fei-Hu Gong, Chuan-Gui Li, Chi Zhang ,Yan-Jie Wang, Yun-Gen Xu, Li-Ping Sun*, Design and discovery of 4-anilinoquinazoline-acylamino derivatives as EGFR and VEGFR-2 dual TK inhibitors. Eur. J. Med. Chem. 2016, 109, 371-379.
2. Sheng-Wei Yang, Chun-Meng Wang, Kaixiang Tang, Jin-Xin Wang and Li-Ping Sun*, An Efficient Approach to the Total Synthesis of Ammosamide B. Eur. J. Org. Chem. 2016, 5, 1050-1053.
3. Meining Wang, Aijun Shen, Chi Zhang, Zilan Song,Jing Ai,Hongchun Liu, Liping Sun,*,Jian Ding, Meiyu Geng,*,and Ao Zhang*, Development of Heat Shock Protein (Hsp90) Inhibitors To Combat Resistance to Tyrosine Kinase Inhibitors through Hsp90−Kinase Interactions, J. Med. Chem.  2016, 59, 5563−5586.
4.Ya-Hui Deng, Dan Xu, Ye-Xiang Su, Yi-Juan Cheng, Yan-Li Yang, Xiu-Yun Wang, Juan Zhang, Qi-Dong You* and Li-Ping Sun*,Synthesis and Biological Evaluation of Novel Oxazolo[5,4-d]pyrimidines as Potent VEGFR-2 Inhibitors. Chem. Biodivers. 2015, 12, 528-537.
5.Ji-Ping Liu, Ya-Hui Deng, Ling Yang,Yi-Juan Cheng, Lawali Manzo, Li-Ping Sun*and Yu Liu*, CPU-12, a novel synthesized oxazolo[5,4-d]pyrimidine derivative, showed superior anti-angiogenic activity, J. Pharmacol. Sci. 2015, 129, 9-17.
6. Chi Zhang, Mei-Ning Wang, Zhou-Long Fan, Li-Ping Sun* and Ao Zhang*, Substituent-Enabled Oxidative Dehydrogenative Cross-Coupling of 1,4-Naphthoquinones with Alkenes. J.Org. Chem.2014, 79, 7626-7632.
7. Sheng-Wei Yang, Ye-Xiang Su, Li-Ping Sun*,Palladium-catalyzed oxidative C-H/C-H cross-couplings of thiazolo [5,4-d]pyrimidine with aromatic (hetero)cycles. Tetrahedron. 2014, 70, 3730-3734.
8.Mei-Ning Wang, Chi Zhang, Li-Ping Sun, Ao Zhang, Naphthoquinone-Directed C-H Annulation and C-sp3-H Bond Cleavage: One-Pot Synthesis of Tetracyclic Naphthoxazoles. J. Org. Chem.2014, 79, 4553-4560.
9. Yi-Juan Cheng, Li-Ping Sun*, Research Progress towards Copper-Catalyzed Coupling Reactions for C-N Bonds and C-O Bonds. Chin. J. Org. Chem. 2013, 33, 877-890.
10.Ye-Xiang Su,Ya-Hui Deng,Ting-Ting Ma,Yu-Yan Li, Li-Ping Sun*,“On Water” direct Pd-catalysed C-H arylation of thiazolo[5,4-d]pyrimidine derivatives. Green Chem. 2012, 14, 1979–1481.
11. Ling-Yi Huang, Zhen-Gui Huang, Zhi-Giang Bai, Rui Xie, Li-Ping Sun*and Ke-Jiang Lin*, Development and strategies of VEGFR-2/KDR inhibitors. Future Med. Chem. 2012, 4, 1839-1852 .
12.Dan Xu, Li-Ping Sun*, Qi-Dong You, Facile synthesis of 2,5,7-trisubstituted oxazolo[5,4-d]pyrimidines via copper-catalyzed intramolecular C-O bond formation.Tetrahedron. 2012, 68,4248–4251.
13. Ye-Xiang Su,Li-Ping Sun*, Recent progress towards transition-metal-catalyzed directarylation of heteroarenes, Mini. Rev. Org. Chem. 2012, 9, 87–117.
14. Dan Xu, Li-Ping Sun*, Qi-Dong You*, Recent Progress of Small Molecular VEGFRInhibitors for Pathological Angiogenesis as Anticancer Agents, Mini. Rev. Med. Chem.2011, 2011, 11, 18-31.
15. Dan Xu, Li-Ping Sun*, Qi-Dong You, Pharmacophore modeling and in silico screeningstudies to design potential KDR kinase inhibitors, Chin. J. Chem. 2011, 29, 1107–1113.
16. Qi-Fei Zhong, Li-Ping Sun*, An efficient synthesis of 6, 9-disubstituted purin-8-onesvia copper-catalyzed coupling/cyclization, Tetrahedron 2010, 66, 5107–5111.
专著教材:
 参编专著:1. 化学化工信息及网络资源的检索与利用(第二版),王荣民主编,化学工业出版社(2007年5月)
            2. 药物合成反应,姚其正主编,化学工业出版社(2012年8月)
联络方式
E-mail:chslp@cpu.edu.cn, chsunlp@163.com