余伯阳

    余伯阳,男,1959年3月生,教授、博士生导师。现任中国药科大学研究生院常务副院长;江苏省中西医结合一级学科重点学科学科带头人,江苏省中药评价与转化重点实验室主任。全国首批新世纪“百千万人才工程”国家级人选,享受国务院颁发的政府特殊津贴的专家,江苏省跨世纪学术带头人,江苏省有突出贡献的中青年专家,江苏省"333人才工程"(第二层次)人选,霍英东教育基金会第五届高等院校青年教师奖(研究类)获得者,教育部高校优秀骨干教师。兼任国家药典委员会委员,国务院学位委员会学科评议组成员,全国药学专业学位研究生教育指导委员会秘书长,国家新药审评专家,国家药品价格评审专家,江苏省政协常委等职务。

1989年毕业于中国药科大学生药学专业获理学博士学位,导师为徐国均院士。1988年在日本昭和大学药学部任客座研究员,1995年在美国伊利诺大学芝加哥分校药学院从事博士后研究工作,1996年至1997年在美国依阿华大学药学院任访问教授。
 
研究方向与研究兴趣:
1、中药及复方药效物质基础及作用机理研究(中西医结合基础(药学)):利用化学与生物学相结合的方式,探索构建物质基础与作用机制综合分析研究体系用于中药复方的评价研究。建立了整合指纹图谱等分析技术,开展多组分协同作用、毒效相关分析、体内外效应物质相关分析等研究;经典复方的组方原理与组方优化研究;源于疗效确切的著名中成药的组方优化与二次开发研究
 
主要研究成果:
先后承担国家863重大新药创制项目、国家自然科学基金重大专项、国家科技支撑计划等研究项目30多项;研究成果曾获国家科技进步一等、二等、三等奖各1项,教育部高等学校科学研究优秀成果奖二等奖(自然科学类)1项,省部级科技进步一等奖3项、二等奖3项。近年来,申请发明专利30多项,其中授权10多项,发表论文200多篇,其中SCI收录100多篇。
 
联系方式:
地址:南京市江宁大学城龙眠大道639号,中国药科大学研究生院
邮编:211198
电话:025-86185157-8001;02586185287
邮箱:boyangyucpu@163.com
 
近五年来发表的代表性学术论文:
1.Identification and Determination of the Major Triterpenes in RhizomaAlismatis by HPLC-Evaporative Light Scattering Detection and HPLC/Electrospray Ionization-MSn [J] Journal of AOAC International. 2013, 96(2): 260-264.
2.Effect of Kai Xin San on Learning and Memory in a Rat Model of Paradoxical Sleep Deprivation [J]. Journal of medicinal food. 2013, 16(4): 280-287.
3.A facile drug delivery system preparation through the interaction between drug and iron ion of transferring [J]. Journal of Nanoparticle Research. 2013, 15(9): 1-12.
4.Diosgenin down-regulates NF-κB p65/p50 and p38MAPK pathways and attenuates acute lung injury induced by lipopolysaccharide in mice. [J] International Immunopharmacology, 2013, 15: 240-245.
5.Screening and identifying the myocardial-injury protective ingredients from Sheng-Mai-San. Pharmaceutical Biology, 2013, 51(10): 1219-1227.
6.Ruscogenin reduces cerebral ischemic injury via NF-κB-mediated inflammatory pathway in the mouse model of experimental stroke. European Journal of Pharmacology, 2013, 714: 303-311.
7.Ruscogenin inhibits lipopolysaccharide-induced acute lung injury in mice: Involvement of tissue factor, inducible NO synthase and nuclear factor (NF)-κB. Int Immunopharmacol. 2012, 12(1): 88-92.
8.Regio- and enantio- selective glycosylation of tetrahydroprotoberberines by Gliocladium deliquescens NRRL1086 resulting in unique alkaloidal glycosides. Appl Microbiol Biot, 2012, 93: 2357–2364.
9.Antioxidant anthocyanins screening through spectrum–effect relationships and DPPH-HPLC-DAD analysis on nine cultivars of introduced rabbiteye blueberry in China. Food Chem, 2012, 132: 759–765.
10.Efficient synthesis of Guanfu base G via highly regioselective lipase-catalyzed acylation in non-aqueous phase. Bioorg Med Chem Lett.2012, 22(9): 3100-3103.
11.Ginsenoside Rg1 protects against hydrogen peroxide-induced cell death in PC12 cells via inhibiting NF-kB activation. Neurochem Int, 2011, 58(1): 119-125.
12.Safety evaluation of steroidal saponin DT-13 isolated from the tuber of Liriope muscari (Decne.) Baily. Food Chem Toxicol, 2011, 49(9): 2243-2251.
13.New approaches to the structural modification of olean-type pentacylic triterpenes via microbial oxidation and glycosylation. Tetrahedron, 2011, 67(23): 4206-4211.
14.On-line high-performance liquid chromatography–diode array detection–electrospray ionization–mass spectrometry–chemiluminescence assay of radical scavengers in Epimedium. J Chromatogr A, 2011, 121(9): 1227-1235.
15. Two new benzofuran derivatives with anti-inflammatory activity from Liriope spicata var. prolifera. Fitoterapia, 2011, 82(2): 190–192.
16. Identification of multiple constituents in the traditional Chinese medicine formula Sheng-Mai San and rat plasma after oral administration by HPLC–DAD–MS/MS. J Pharmaceut Biomed,2011,54 (5): 1110–1127.
18.A new sol–gel silica nanovehicle preparation for photodynamic therapy in vitro. Int J Pharmaceut, 2010, 386(12): 131–137.
19.Effects of Storage Condition Factors on Fungal Invasion of Radix Ophiopogonis. J Agric Food Chem, 2010, 58(9): 5432-5437.
20. Homoisoflavonoids from the Fibrous Roots of Polygonatum odoratum with Glucose Uptake-Stimulatory Activity in 3T3-L1 Adipocytes. J Nat Prod, 2010, 73(4): 548–552.
21. One unique steroidal sapogenin obtained through the microbial transformation of ruscogenin by Phytophthora cactorum ATCC 32134 and its potential inhibitory effect on tissue factor (TF) procoagulant activity. Bioorg Med Chem Lett, 2010, 20(14): 4015-4017.
22.Quality and antioxidant activity detection of Crataegus leaves using on-line high-performance liquid chromatography with diode array detector coupled to chemiluminescence detection. Food Chem, 2010, 120(3): 929-933.
23. Microbial conversion of ruscogenin by Gliocladium deliquescens NRRL1086: glycosylation at C-1. Appl Microbiol Biot, 2010, 86(2): 491-497.
24.Isolation and Anti-Inflammatory Activity Evaluation of Triterpenoids and a Monoterpenoid Glycoside from Harpagophytum procumbens. Planta Med, 2010, 76(16): 1892–1896.
25.Biotransformation of Bioactive Natural Products for Pharmaceutical Lead Compounds. Curr Org Chem, 2010, 14(14): 1400-1406.
26.Quality control of flavonoids in Ginkgo biloba leaves by high-performance liquid chromatography with diode array detection and on-line radical scavenging activity detection. J Chrom. A, 2009,1216: 2204–2210
27.The antioxidant-activity-integrated fingerprint: An advantageous tool for the evaluation of quality of herbal medicines. J Chromatogr A. 2008, 1208(1-2):76-82
28.Evaluation of the analgesic and anti-inflammatory activities of Liu-Shen-Wan and its individual fractions in mice. J Ethnopharmacol., 2007,117:108-114
29.Determination of   glycyrrhizin in        Chinese prescriptions and biological samples by enzyme-linked immunosorbent assay. Analytica Chimica Acta 2006; 564(2):173-178
30.Novel biotransformation of pentacyclic triterpenoid acids by Nocardia sp. NRRL 5646. Tetrahedron Letter,2005,46,2337-2340