洪浩

洪浩Hao Hong),博士,药学院药理系教授,博士生导师,课题组长,教育部创新团队成员,“药理公共实验平台负责人,神经精神疾病靶标发现与新药评价校级重点实验室主任。兼任中国药理学会神经精神药理专业委员会常务委员、抗衰老与老年痴呆专业委员会常务委员、江苏省首席科技传播专家、江苏省药理学会教学专业委员会秘书长、中国医学教育题库(人民卫生出版社)药理学主编、神经药理学报编委、美国“Metabolic Brain Disease”杂志副主编。洪浩教授于19896月毕业于中国药科大学,20016月获安徽中医学院医学硕士学位,20046月获中国药科大学理(药)学博士学位,200510月至200610月在日本Kinki University任访问学者,201612月至20175月在美国Auburn University任高级研究学者。主持承担国家自然科学基金及重大新药创制等国家和省部级项目共计6项。以第一作者或通讯作者在国际知名杂志如Brain Behav Immun, Br J PharmacolNeuropharmacologyInt J NeuropsychopharmacolPsychopharmacologyNeurobiology of Aging等发表SCI收录的论文50余篇,获发明专利2项;参编中英文著作各1部。

研究方向:

神经精神药理。以生物信息学和流行病学大数据为导向,采用分子遗传学、光遗传学、化学遗传学、工具病毒、光纤记录、细胞分子生物学以及动物行为学等方法手段,探寻参与并调控阿尔茨海默病(AD)与抑郁症发生发展的关键分子和关键神经环路,确证其作为药物调控靶标,并以此为基础发掘活性物质、开发防治药物。当前作为课题负责人正在承担的课题有国家自然科学基金面上项目2项。已获得一些国内外同行公认的研究成果如半胱氨酰白三烯受体 1(CysLT1R)参与多种因素所致的学习记忆损害以及过氧化物酶体增殖物激活受体δPPARδ)调控应激诱导的抑郁样行为。近期研究发现,MS-MHb胆碱能神经环路参与并调控厌恶记忆泛化与消退,从全新的角度揭示抑郁症、焦虑症以及创伤后应激障碍(PTSD)发病的新机制。

联系方式

honghao@cpu.edu.cn;江宁校区学院新实验楼543室。

5年发表的代表性论文:

1. Chen F, Ghosh A, Lin J, Zhang C, Pan Y, Thakur A, Singh K, Hong H*, Tang S*. 5-lipoxygenase pathway and its downstream cysteinyl leukotrienes as potential therapeutic targets for Alzheimer's disease. Brain Behav Immun. 2020 Mar 25. pii: S0889-1591(19)31484-9.

2. Liu CH, Tan YZ, Li DD, Tang SS, Wen XA, Long Y, Sun HB, Hong H*, Hu M*. Zileuton ameliorates depressive-like behaviors, hippocampal neuroinflammation, apoptosis and synapse dysfunction in mice exposed to chronic mild stress. Int Immunopharmacol. 2020 Jan;78:105947. doi: 10.1016/j.intimp.2019.105947.

3. Chen F, Yu X, Meng G, Mei Z, Du Y, Sun H, Reed MN, Kong L, Suppiramaniam V, Hong H*, Tang S*. Hippocampal Genetic Knockdown of PPARδ Causes Depression-Like Behaviors and Neurogenesis Suppression. Int J Neuropsychopharmacol. 2019;22(6):372-382.

4. Mu RH, Tan YZ, Fu LL, Nazmul Islam M, Hu M, Hong H*, Tang SS*. 1-Methylnicotinamide attenuates lipopolysaccharide-induced cognitive deficits via targeting neuroinflammation and neuronal apoptosis. Int Immunopharmacol. 2019 Dec;77:105918. doi: 10.1016/j.intimp.2019.105918.

5. Wu X, Liu C, Chen L, Du YF, Hu M, Reed MN, Long Y, Suppiramaniam V, Hong H*, Tang SS*. Protective effects of tauroursodeoxycholic acid on lipopolysaccharide-induced cognitive impairment and neurotoxicity in mice. Int Immunopharmacol. 2019; 72:166-175.

6. Fu L, Liu C, Chen L, Lv Y, Meng G, Hu M, Long Y, Hong H*, Tang S*. Protective Effects of 1-Methylnicotinamide on Aβ1-42-Induced Cognitive Deficits, Neuroinflammation and Apoptosis in Mice. J Neuroimmune Pharmacol. 2019;14(3):401-412.

7. Wu X, Lv YG, Du YF, Hu M, Reed MN, Long Y, Suppiramaniam V, Hong H*, Tang SS*. Inhibitory effect of INT-777 on lipopolysaccharide-induced cognitive impairment, neuroinflammation, apoptosis, and synaptic dysfunction in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2019; 88:360-374.

8.Wu X, Lv YG, Du YF, Chen F, Reed MN, Hu M, Suppiramaniam V, Tang SS*, Hong H*. Neuroprotective effects of INT-777 against Aβ1-42-induced cognitive impairment, neuroinflammation, apoptosis, and synaptic dysfunction in mice. Brain Behav Immun. 2018;73:533-545.

9. Wang H, Chen F, Du YF, Long Y, Reed MN, Hu M, Suppiramaniam V, Hong H*, Tang SS*.Targeted inhibition of RAGE reduces amyloid-β influx across the blood-brain barrier and improves cognitive deficits in db/db mice. Neuropharmacology. 2018;131:143-153.

10. Li DD, Xie H, Du YF, Long Y, Reed MN, Hu M, Suppiramaniam V, Hong H*, Tang SS*. Antidepressant-like effect of zileuton is accompanied by hippocampal neuroinflammation reduction and CREB/BDNF upregulation in lipopolysaccharide-challenged mice. J Affect Disord. 2018; 227:672-680.

11. Chen F, Ghosh A, Hu M, Long Y, Sun H, Kong L, Hong H*, Tang S*. RAGE-NF-κB-PPARγ Signaling is Involved in AGEs-Induced Upregulation of Amyloid-β Influx Transport in an In Vitro BBB Model. Neurotox Res. 2018;33(2):284-299.

12.Chen F, Ghosh A, Wu F, Tang S, Hu M, Sun H, Kong L, Hong H*. Preventive effect of genetic knockdown and pharmacological blockade of CysLT1R on lipopolysaccharide (LPS)-induced memory deficit and neurotoxicity in vivo. Brain Behav Immun. 2017; 60:255-269.

13.Ghosh A, Chen F, Wu F, Tang SS, Hu M, Long Y, Sun HB, Kong LY, Hong H*. CysLT1R downregulation reverses intracerebroventricular streptozotocin-induced memory impairment via modulation of neuroinflammation in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2017;73:19-30.

14. Fang SC, Xie H, Chen F, Hu M, Long Y, Sun HB, Kong LY, Hong H*, Tang SS*. Simvastatin ameliorates memory impairment and neurotoxicity in streptozotocin-induced diabetic mice. Neuroscience. 2017;355:200-211.

15.Lin JR, Fang SC, Tang SS, Hu M, Long Y, Ghosh A, Sun HB, Kong LY, Hong H*. Hippocampal CysLT1R knockdown or blockade represses LPS-induced depressive behaviors and neuroinflammatory response in mice. Acta Pharmacol Sin. 2017;38(4):477-487.

16.Wang H, Chen F, Zhong KL, Tang SS, Hu M, Long Y, Miao MX, Liao JM, Sun HB, Hong H*. PPARγ agonists regulate bidirectional transport of amyloid-β across the blood-brain barrier and hippocampus plasticity in db/db mice. Br J Pharmacol. 2016; 173(2):372-385.

17. Chen F, Dong RR, Zhong KL, Ghosh A, Tang SS, Long Y, Hu M, Miao MX, Liao JM, Sun HB, Kong LY, Hong H*. Antidiabetic drugs restore abnormal transport of amyloid-β across the blood-brain barrier and memory impairment in db/db mice. Neuropharmacology, 2016; 101:123-136.

18.Yu XB, Dong RR, Wang H, Lin JR, An YQ, Du Y, Tang SS, Hu M, Long Y, Sun HB, Kong LY, Hong H*. Knockdown of hippocampal cysteinyl leukotriene receptor 1 ameliorates depressive behavior and neuroinflammation induced by chronic mild stress in mice. Psychopharmacology, 2016; 233(9):1739-1749.

19.Ji MJ, Yu XB, Mei ZL, An YQ, Tang SS, Hu M, Long Y, Miao MX, Hu QH, Sun HB, Kong LY, Hong H*. Hippocampal PPARδ overexpression or activation represses stress-induced depressive behaviors and enhances neurogenesis. Int J Neuropsychopharmacol. 2016; 19(1):1-16.

20.Ghosh A, Chen F, Thakur A, Hong H*. Cysteinyl Leukotrienes and Their Receptors: Emerging Therapeutic Targets in Central Nervous System Disorders. CNS Neurosci Ther. 2016;22(12):943-951.