丁娅

丁娅女,教授,博士生导师。教育部新世纪优秀人才支持计划(2010),江苏省青蓝工程优秀青年骨干教师(2010),江苏省第五期“333高层次人才培养工程培养对象(2016)。从事纳米药物分析和药物光谱分析相关研究,在纳米科技和药物材料研究方面的国际著名学术期刊:ACS Nano, Adv Sci, Biomaterials, ACS Appl. Mat. Interfaces, Mol Ther, Chem Eur J等发表论文40余篇,拥有专利5项。获高等学校科学研究优秀成果奖,自然科学奖,一等奖1项(2011)。《有机光谱分析》教材编委,人民卫生出版社(2009)。Anal Chem, Biomaterials, Bioconjgate Chem, Theranostics, Polym Chem, Mol Pharm等期刊的审稿人。作为负责人主持国家自然科学基金项目3项,中国博士后基金2项,省部级基金项目5项。《药学学报》青年编委,《中国化学快报, CCL》通讯编委,中国化学会会员,美国化学会会员,中美纳米医学与纳米生物技术学会(CASNN)终身会员,中国微米纳米技术学会高级会员,中国医药生物技术协会纳米生物技术分会常务委员,中国抗癌协会纳米肿瘤学专业委员会青年委员会委员。

Ÿ联系方式:

E-mail: dingya@cpu.edu.cn电话:189-1594-8060

Ÿ主要研究方向:

药物分析新材料和新技术;纳米材料质量标准建立。

Ÿ教育和工作经历:

2017 - 迄今,中国药科大学,教授;

2015 - 2017年,中国药科大学,特聘研究员;

2013 - 2014年,University of Massachusetts-Amherst,化学系,访问学者,合作导师:Vince M. Rotello 教授;

2008 - 2012年,南京大学,生命科学学院,生物学博士后,导师:张峻峰教授;

2007 - 2015年,中国药科大学,讲师、副教授;

2004 - 2007年,南京大学,化学化工学院,分析化学博士,导师:夏兴华教授;

2001 - 2004年,中国药科大学,药物化学硕士,导师:张灿教授;

1995 - 1999年,中国药科大学,化学制药学士。

Ÿ承担项目:

1.国家自然科学基金面上项目:蒲公英型异质纳米囊泡对肿瘤细胞表面的在体改造用于黑色素瘤免疫治疗研究31870946

2.国家自然科学基金面上项目:金纳米结合物用于肿瘤靶向治疗及其构效关系研究 31470916

3.国家自然科学基金青年科学基金项目:金纳米结合物作为肝肿瘤靶向治疗系统的构建和研究 30900337

4.教育部新世纪优秀人才支持计划” NCET-10-0816

5.教育部博士点新教师基金20090096120001

6.第三批中国博士后科学基金特别资助(化学)

7.第四十四批博士后科学基金面上资助(一等资助)

Ÿ代表性论文(近5年):

1.X.-S. Hou, H.-S. Wang (co-first author), B. P. Mugaka, G.-J. Yang*, Y. Ding*, Mitochondria: Promising organelle target for cancer diagnosis and treatment. Biomater. Sci.2018. DOI: 10.1039/C8BM00673C. (SCI IF=5.831) (Back Cover)

2.J. Hong, Y.-F. Chen (co-first author), Y. Ma, F.-F. Zhang, C.-M. Wang, Y. Ding*, Surface modifier effects on gold nanoprobe for the assay of matrix metalloproteinases. Adv. Biosyst.2018. DOI: 10.1002/adbi.201800115. (SCI IF=N/A) (Back Cover)

3.Y. Niu, Q. Li, Y. Ding, L. Dong, C. Wang*, Engineered delivery strategies for enhanced control of growth factor activities in wound healing. Adv. Drug Delivery Rev.2018, in press. DOI: 10.1016/j.addr.2018.06.002 (SCI IF=11.764)

4.J.-J. Shen, P.-H. Zhang, F. Zheng, W. Chen, H.-S. Wang, Y. Ding*, X.-H. Xia, Formulation of preliminary quality criteria of gold nanoparticles for the medicinal applications. ACS Appl. Nano Mater. 2018. DOI: 10.1021/acsanm.8b00192 (SCI IF N/A)

5.H. Zhang, Z. Yang, Y. Ju, X. Chu, Y. Ding, X. Huang, K. Zhu, T. Tang, S. Qiao, X. Su*, Y. Hou*, Galvanic displacement synthesis of monodisperse Janus- and satellite-like plasmonic-magnetic Ag-Fe@Fe3O4 heterostructures with reduced cytotoxicity. Adv. Sci. 2018, 1800271. (SCI IF=9.034)

6.J.-J. Shen, J. He, Y. Ding*, Preparation, stabilization, and self-assembly of gold nanoparticles by chitosan derivatives. Adv. Mater. Lett.2018, in press. DOI: (SCI IF=1.46)

7.H.-S. Wang, J. He, Y. Ding*, X.-H. Xia, Preparation of sulfonated chitosan-modified gold nanoparticles and their surface electronic payload of cationic drugs. Science in China (life sciences) 2018, 61, 457-463. (SCI IF=2.781)

8.D.-Y. Wu, H.-S. Wang, X.-S. Hou, H. Chen, Y. Ma, Y. Hou*, J. Hong, Y. Ding*, Effects of gold core size on regulating the performance of Doxorubicin-conjugated gold nanoparticles. Nano Res. 2018, 11, 3396-3410. (SCI IF=7.392)

9.H.-S. Wang, H.-L. Liu, K. Wang, Y. Ding*, J.-J. Xu, X.-H. Xia*, H.-Y. Chen, Insight into the Unique Fluorescence Quenching Property of Metal-Organic Frameworks upon DNA Binding. Anal. Chem. 2017, 89, 11366-11371. (SCI IF=5.886)

10.Y.-Y. Gao, H. Chen, Y.-Y. Zhou, L.-T. Wang, Y. Hou*, X.-H. Xia, Y. Ding*, Intraorgan Targeting of Gold Conjugates for Precise Liver Cancer Treatment. ACS Appl. Mater. Interf.2017, 9, 31458–31468. (SCI IF=7.145)

11.Y. Ju, H. Zhang, J. Yu*, S. Tong, N. Tian, Z. Wang, X. Wang, X. Su, X. Chu, J. Lin, Y. Ding, G. Li, F. Sheng*, Y. Hou*, Monodisperse Au-Fe2C Janus Nanoparticles: an Attractive Multifunctional Material for Triple-Modal Imaging-Guided Tumor Photothermal Therapy. ACS Nano 2017, 11, 9239-9248. (SCI IF=13.942)

12.J. Hong, Y.-F. Chen, J.-J. Shen, Y. Ding*, Noninvasive Detection and Imaging of Matrix Metalloproteinases for Cancer Diagnosis. J. Anal. Test 2017, 1, 203-212. (SCI IF=N/A)

13.T. Cui, J.-J. Liang, H. Chen, D.-D. Geng, L. Jiao, J.-Y. Yang, H. Q., C. Zhang*, Y. Ding*, The performance of Doxorubicin-conjugated gold nanoparticles: Regulation of drug location. ACS Appl. Mater. Interf.2017, 2017, 9, 8569–8580. (SCI IF=7.145)

14.H.-S. Wang, J. Li, J.-Y. Li, K. Wang, Y. Ding, X.-H. Xia*, Lanthanide-based metal-organic framework nanosheets with unique fluorescence quenching properties for two-color intracellular adenosine imaging in living cells. NPG Asia Mater.2017, 9, e354. (SCI IF=8.772)

15.D.-Y. Wu, Y. Ma, X.-S. Hou, P. Wang, H. Chen, C. Zhang, Y. Ding*, Co-delivery of antineoplastic and protein drugs by chitosan nanocapsules for a collaborative tumor treatment. Carbohydr. Polym.2017, 157, 1470–1478. (SCI IF=4.219)

16.Q.-Y. Bao, A.-Y. Liu, Y. Ma, H. Chen, J. Hong, W.-B. Shen, C. Zhang, Y. Ding*, The effect of oil-water partition coefficient on the distribution and cellular uptake of liposome-encapsulated gold nanoparticles. Colloid. Surf. B2016, 146, 475–481. (SCI IF=3.902)

17.Y.-F. Chen, J. Hong, D.-Y. Wu, Y.-Y. Zhou, M. D’Ortenzio, Y. Ding*, Xing-Hua Xia, In vivo mapping and assay of matrix metalloproteases for the liver tumor diagnosis. RSC Adv.2016, 6, 8336–8345. (SCI IF=3.289)

18.N. Zhang, H. Chen, A.-Y. Liu, J.-J. Shen, V. Shah, C. Zhang, J. Hong, Y. Ding*, Gold conjugate-based liposomes with hybrid Cluster Bomb structure for liver cancer therapy. Biomaterials2016, 74, 280–291. (SCI IF=8.387)

19.F.-F. Zhang, Y.-Q. Zhao, J.-P. Fan, L.-G. Liu, R.-W. Li, W.-B. Shen*, Y. Ding*, Structural identification of 4-benzyl-voglibose hydrochloride monohydrate via NMR and single-crystal X-ray diffraction methods. Carbohydr. Res.2015, 402, 81–86. (SCI IF=1.966)

20.F.-F. Zhang, M.-H. Jiang, L.-L. Sun, F. Zheng, L. Dong, V. Shah, W.-B. Shen*, Y. Ding*, Quantitative analysis of Sitagliptin using 19F-NMR method: A universal technique for fluorinated compounds detection. Analyst2015, 140, 280–286. (SCI IF=3.906)

21.J.-J. Liang, Y.-Y. Zhou, J. Wu, Y. Ding*, Gold nanoparticle-based drug delivery platform for antineoplastic chemotherapy. Curr. Drug Met.2014, 15, 620–631. (SCI IF=3.487)

22.Y. Ding, Z. Jiang, K. Saha, C. S. Kim, S. T. Kim, R. F. Landis, V. Rotello*, Gold nanoparticles for nucleic acid delivery. Mol. Ther.2014, 22, 1075–1083. (SCI IF=6.425, 高引用论文)

23.Y. Ding, J.-J. Liang, Z.-Y. Liu, D. Wu, L. Dong, X.-H. Xia*, W.-B. Shen, Can Zhang*, Development of a liver-targeting gold-PEG-galactose nanoparticle platform and the structure-function study. Part. Part. Syst. Charact.2014, 31, 347–356. (SCI IF=3.868)

24.Y. Ding*, Y.-Y. Zhou, H. Chen, D.-D. Geng, D.-Y. Wu, J. Hong, W.-B. Shen, T.-J. Hang, C. Zhang, The performance of thiol-terminated PEG-paclitaxel-conjugated gold nanoparticles. Biomaterials2013, 34, 10217–10227. (SCI IF 8.312)

25.Q.-Y. Bao, D.-D. Geng, J.-W. Xue, G. Zhou, S.-Y. Gu, Y. Ding*, C. Zhang*, Glutathione-mediated drug release from Tiopronin-conjugated gold nanoparticles for acute liver injury therapy. Inter. J. Pharm.2013, 446, 112–118. (SCI IF=3.789)

Ÿ获得奖励:

1.International Association of Advanced Materials (IAAM),IAAM Medal”(2017

2.“岛津青年学者奖”(2017

3.江苏省第五期“333高层次人才培养工程培养对象(第三层次,2016

4.第一届先进材料前沿学术会议,优秀报告奖(邀请报告,2016

5.《中国药科大学学报》最具学术影响力优秀论文最受读者关注优秀论文2014

6.国家留学基金委访问学者项目(自由申请,2012

7.高等学校科学研究优秀成果奖,自然科学奖,一等奖(2011-022)(2011

8.教育部“新世纪优秀人才支持计划”(2010

9.江苏省高校青蓝工程优秀青年骨干教师培养对象(2010

10.中国药科大学校级精品课程《有机光谱分析》(2010,排名第1

11.中国化学会分析化学委员会授予优秀论文奖2006,排名第1

Ÿ获得专利:

1.丁娅,张灿,张文婕,耿冬冬,梁娟娟,一种金纳米蒽环类药物结合物及其制备方法和应用,专利号:ZL 2014 1 0246681.X

2.丁娅,张灿,刘肇彧,吴迪,洪谨,张文婕,一种金纳米-紫杉醇结合物及其制备方法和应用,专利号:ZL 2011 1 0092881.0

3.夏兴华,丁娅,碳纳米空心球负载金属纳米粒子催化剂的制备方法,专利号:ZL 2005 1 0040199.1

4.平其能,张灿,丁娅,朱贤,季铵化壳聚糖衍生物、其制备方法及含其的药物制剂,专利号:ZL 2005 1 0095442.X

5.平其能,张灿,张宏娟,丁娅,程耀,壳聚糖衍生物及其制备方法与在制药中的应用,专利号:ZL 03 1 12981.1